Literature DB >> 17274084

Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution.

Marcel Reese1, Víctor M Sánchez-Pedregal, Karel Kubicek, Jens Meiler, Marcel J J Blommers, Christian Griesinger, Teresa Carlomagno.   

Abstract

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Year:  2007        PMID： 17274084     DOI： 10.1002/anie.200604505

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  21 in total

1.  Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.

Authors:  Enrique Calvo; Isabel Barasoain; Ruth Matesanz; Benet Pera; Emilio Camafeita; Oriol Pineda; Ernest Hamel; Christopher D Vanderwal; José Manuel Andreu; Juan A López; José Fernando Díaz
Journal:  Biochemistry       Date:  2011-12-30       Impact factor: 3.162

2.  Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

Authors:  Jessica J Field; Benet Pera; Enrique Calvo; Angeles Canales; Didier Zurwerra; Chiara Trigili; Javier Rodríguez-Salarichs; Ruth Matesanz; Arun Kanakkanthara; St John Wakefield; A Jonathan Singh; Jesús Jiménez-Barbero; Peter Northcote; John H Miller; Juan Antonio López; Ernest Hamel; Isabel Barasoain; Karl-Heinz Altmann; José Fernando Díaz
Journal:  Chem Biol       Date:  2012-06-22

Review 3.  Drug discovery targeting cell division proteins, microtubules and FtsZ.

Authors:  Iwao Ojima; Kunal Kumar; Divya Awasthi; Jacob G Vineberg
Journal:  Bioorg Med Chem       Date:  2014-03-05       Impact factor: 3.641

4.  Data quality in drug discovery: the role of analytical performance in ligand binding assays.

Authors:  Hermann Wätzig; Imke Oltmann-Norden; Franziska Steinicke; Hassan A Alhazmi; Markus Nachbar; Deia Abd El-Hady; Hassan M Albishri; Knut Baumann; Thomas Exner; Frank M Böckler; Sami El Deeb
Journal:  J Comput Aided Mol Des       Date:  2015-06-13       Impact factor: 3.686

5.  Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling.

Authors:  Ruth A Entwistle; Rania S Rizk; Daniel M Cheng; Gerald H Lushington; Richard H Himes; Mohan L Gupta
Journal:  ChemMedChem       Date:  2012-07-16       Impact factor: 3.466

6.  Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin.

Authors:  Adwait R Ranade; LeeAnn Higgins; Todd W Markowski; Nicole Glaser; Dmitry Kashin; Ruoli Bai; Kwon Ho Hong; Ernest Hamel; Gerhard Höfle; Gunda I Georg
Journal:  J Med Chem       Date:  2016-03-17       Impact factor: 7.446

Review 7.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

Review 8.  Targeting microtubules by natural agents for cancer therapy.

Authors:  Eiman Mukhtar; Vaqar Mustafa Adhami; Hasan Mukhtar
Journal:  Mol Cancer Ther       Date:  2014-01-16       Impact factor: 6.261

9.  Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.

Authors:  Emily A Reiff; Sajiv K Nair; John T Henri; Jack F Greiner; Bollu S Reddy; Ramappa Chakrasali; Sunil A David; Ting-Lan Chiu; Elizabeth A Amin; Richard H Himes; David G Vander Velde; Gunda I Georg
Journal:  J Org Chem       Date:  2010-01-01       Impact factor: 4.354

Review 10.  Epothilones: tubulin polymerization as a novel target for prostate cancer therapy.

Authors:  James J Lee; W Kevin Kelly
Journal:  Nat Clin Pract Oncol       Date:  2008-12-02
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