PURPOSE OF REVIEW: High-dose chemotherapy increasingly is being used for the management of patients with immunoglobulin light-chain amyloidosis. We describe nearly 300 patients who had treatment combining high-dose chemotherapy and stem cell transplantation at Mayo Clinic and review the recent literature. RECENT FINDINGS: We review outcomes, engraftment data, and predictors of early mortality. The survival benefit of transplantation, however, has not been verified in a phase III clinical trial. SUMMARY: Partial response rates and complete response rates are prognosticators of survival for patients with amyloidosis. These rates are much higher for patients who receive high-dose therapy and transplantation.
PURPOSE OF REVIEW: High-dose chemotherapy increasingly is being used for the management of patients with immunoglobulin light-chain amyloidosis. We describe nearly 300 patients who had treatment combining high-dose chemotherapy and stem cell transplantation at Mayo Clinic and review the recent literature. RECENT FINDINGS: We review outcomes, engraftment data, and predictors of early mortality. The survival benefit of transplantation, however, has not been verified in a phase III clinical trial. SUMMARY: Partial response rates and complete response rates are prognosticators of survival for patients with amyloidosis. These rates are much higher for patients who receive high-dose therapy and transplantation.
Authors: Maria Teresa Cibeira; Vaishali Sanchorawala; David C Seldin; Karen Quillen; John L Berk; Laura M Dember; Adam Segal; Frederick Ruberg; Hans Meier-Ewert; Nancy T Andrea; J Mark Sloan; Kathleen T Finn; Gheorghe Doros; Joan Blade; Martha Skinner Journal: Blood Date: 2011-08-09 Impact factor: 22.113
Authors: Vaishali Sanchorawala; Jaymin M Patel; J Mark Sloan; Anthony C Shelton; Jerome B Zeldis; David C Seldin Journal: Haematologica Date: 2012-11-09 Impact factor: 9.941
Authors: Raymond Q Migrino; Ravi K Mareedu; Daniel Eastwood; Mark Bowers; Leanne Harmann; Parameswaran Hari Journal: J Am Soc Echocardiogr Date: 2009-10-31 Impact factor: 5.251
Authors: Saulius Girnius; David C Seldin; Martha Skinner; Kathleen T Finn; Karen Quillen; Gheorghe Doros; Vaishali Sanchorawala Journal: Haematologica Date: 2009-05-19 Impact factor: 9.941
Authors: Ping Zhou; Raymond L Comenzo; Adam B Olshen; Ezio Bonvini; Scott Koenig; Peter G Maslak; Martin Fleisher; James Hoffman; Suresh Jhanwar; James W Young; Stephen D Nimer; Adam M Boruchov Journal: Blood Date: 2008-01-23 Impact factor: 22.113