Parametric imaging in dynamic susceptibility contrast MRI-phantom and in vivo studies.

Possibility of quantitative perfusion imaging with DSC MRI is still under discussion. In this work, the quantitative related parameters are analyzed and DSC-MRI limitations are discussed. It includes investigation of measurement procedures/conditions as well as parametric image synthesis methodology. The set of phantoms was constructed and used to inspect the role of Gd-DTPA concentration estimation by EPI measurements, the influence of partial volume effect on concentration estimation, the role of a phantom and its pipes orientation, etc. Additionally, parametric image synthesis methodology was investigated by analysis of influence of a bolus dispersion, bolus arrival time, and other signal parameters on an image quality. As a conclusion testing software package is proposed.