| Literature DB >> 17270443 |
George Burton1, Thomas W Ku, Thomas J Carr, Terry Kiesow, Robert T Sarisky, Juili Lin-Goerke, Glenn A Hofmann, Martin J Slater, David Haigh, Dashyant Dhanak, Victor K Johnson, Nigel R Parry, Pia Thommes.
Abstract
The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon).Entities:
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Year: 2007 PMID： 17270443 DOI： 10.1016/j.bmcl.2007.01.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823