Literature DB >> 17269913

PEGylated dendritic architecture for development of a prolonged drug delivery system for an antitubercular drug.

P Vijayaraj Kumar1, Hrushikesh Agashe, Tathagata Dutta, Narendra K Jain.   

Abstract

The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non-PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.

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Year:  2007        PMID： 17269913     DOI： 10.2174/156720107779314794

Source DB:  PubMed          Journal:  Curr Drug Deliv        ISSN： 1567-2018            Impact factor:   2.565


  8 in total

1.  Exhaustive glycosylation, PEGylation, and glutathionylation of a [G4]-ene(48) dendrimer via photoinduced thiol-ene coupling.

Authors:  Mauro Lo Conte; Maxwell J Robb; Yvonne Hed; Alberto Marra; Michael Malkoch; Craig J Hawker; Alessandro Dondoni
Journal:  J Polym Sci A Polym Chem       Date:  2011-10-15       Impact factor: 2.702

Review 2.  Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine.

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Journal:  Pharmaceutics       Date:  2022-06-17       Impact factor: 6.525

Review 3.  Nanobead-based interventions for the treatment and prevention of tuberculosis.

Authors:  Gareth Griffiths; Bo Nyström; Suraj B Sable; Gopal K Khuller
Journal:  Nat Rev Microbiol       Date:  2010-10-12       Impact factor: 60.633

4.  Novel technologies: A weapon against tuberculosis.

Authors:  B N Vedha Hari; Karuna Priya Chitra; Ramadevi Bhimavarapu; Prabhu Karunakaran; N Muthukrishnan; B Samyuktha Rani
Journal:  Indian J Pharmacol       Date:  2010-12       Impact factor: 1.200

5.  Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates.

Authors:  Suneela Pyreddy; Pandurangan Dinesh Kumar; Palanirajan Vijayaraj Kumar
Journal:  Int J Pharm Investig       Date:  2014-01

Review 6.  Nanomedicines as Drug Delivery Carriers of Anti-Tubercular Drugs: From Pathogenesis to Infection Control.

Authors:  Afzal Hussain; Sima Singh; Sabya Sachi Das; Keshireddy Anjireddy; Subramanian Karpagam; Faiyaz Shakeel
Journal:  Curr Drug Deliv       Date:  2019       Impact factor: 2.565

Review 7.  New Ways to Treat Tuberculosis Using Dendrimers as Nanocarriers.

Authors:  Serge Mignani; Rama Pati Tripathi; Liang Chen; Anne-Marie Caminade; Xiangyang Shi; Jean-Pierre Majoral
Journal:  Pharmaceutics       Date:  2018-07-26       Impact factor: 6.321

Review 8.  Dendrimers as Modulators of Brain Cells.

Authors:  Dusica Maysinger; Qiaochu Zhang; Ashok Kakkar
Journal:  Molecules       Date:  2020-09-30       Impact factor: 4.411
  8 in total

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