UNLABELLED: The aim of our study was to assess serum uric acid (UA) in a large group of females with OSA before treatment (normal UA value is from 2.4 to 5.7 mg/dL). We studied 105 consecutive females (73,3% without estrogen activity), mean age 58.5+/-9.9 years, mean BMI = 33.3+/-8.2 kg/m(2) with OSA (mean AHI = 35.6+/-21.5, mean overnight SaO2=89+/-6.3%). We divided patients in two groups: 1st with hyperuricaemia - UA>5.7mg/dL (53pts, 50.5%) and 2nd with normouricaemia - UA < 5.7mg/dL (52pts, 49.5%). Concentartion of serum uric acid was similar in females with and without estrogen activity. Subjects with hyperuricaemia had significantly higher BMI (p<0,001), lower mean SaO2 (p<0,01) and spent more time in desaturation below 90% (p<0,01). This group had lower FVC, FEV1 i PaO2 (p < 0,001), higher PaCO2 (p <0,01) and morning glucose (p <0,001). Females with OSA and hyperuricaemia presented higher prevalence of systemic hypertension (p < 0,001), coronary artery disease (p < 0,05), diabetes (not significant) and COPD (p < 0,05). Multiple regression analysis revealed relation between serum uric acid, BMI and arterial hypertension. CONCLUSIONS: Hyperuricaemia is frequent in females with OSA. Increased UA levels were related especially to obesity and arterial hypertension. Lower: overnight SaO2, FVC, FEV1, PaO2 and higher glucose concentration and PaCO2 may play role in developing of hyperuricaemia.
UNLABELLED: The aim of our study was to assess serum uric acid (UA) in a large group of females with OSA before treatment (normal UA value is from 2.4 to 5.7 mg/dL). We studied 105 consecutive females (73,3% without estrogen activity), mean age 58.5+/-9.9 years, mean BMI = 33.3+/-8.2 kg/m(2) with OSA (mean AHI = 35.6+/-21.5, mean overnight SaO2=89+/-6.3%). We divided patients in two groups: 1st with hyperuricaemia - UA>5.7mg/dL (53pts, 50.5%) and 2nd with normouricaemia - UA < 5.7mg/dL (52pts, 49.5%). Concentartion of serum uric acid was similar in females with and without estrogen activity. Subjects with hyperuricaemia had significantly higher BMI (p<0,001), lower mean SaO2 (p<0,01) and spent more time in desaturation below 90% (p<0,01). This group had lower FVC, FEV1 i PaO2 (p < 0,001), higher PaCO2 (p <0,01) and morning glucose (p <0,001). Females with OSA and hyperuricaemia presented higher prevalence of systemic hypertension (p < 0,001), coronary artery disease (p < 0,05), diabetes (not significant) and COPD (p < 0,05). Multiple regression analysis revealed relation between serum uric acid, BMI and arterial hypertension. CONCLUSIONS: Hyperuricaemia is frequent in females with OSA. Increased UA levels were related especially to obesity and arterial hypertension. Lower: overnight SaO2, FVC, FEV1, PaO2 and higher glucose concentration and PaCO2 may play role in developing of hyperuricaemia.
Authors: Camila Hirotsu; Sergio Tufik; Camila Guindalini; Diego R Mazzotti; Lia R Bittencourt; Monica L Andersen Journal: PLoS One Date: 2013-06-24 Impact factor: 3.240