UNLABELLED: We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were significantly associated with bone's mechanical properties. However, cortical density assessed by pQCT was not associated with mechanical properties. INTRODUCTION: The primary objective of this study was to determine the contribution of cross-sectional geometry (by MRI and pQCT) and density (by pQCT and DXA) to mechanical properties of the human cadaveric tibia. METHODS: We assessed 20 human cadaveric tibiae. Bone cross-sectional geometry variables (total area, cortical area, and section modulus) were measured with MRI and pQCT. Cortical density and areal BMD were measured with pQCT and DXA, respectively. The specimens were tested to failure in a four-point bending apparatus. Coefficients of determination between imaging variables of interest and mechanical properties were determined. RESULTS: Cross-sectional geometry measurements from MRI and pQCT were strongly correlated with bone mechanical properties (r(2) range from 0.55 to 0.85). Bone cross-sectional geometry measured by MRI explained a proportion of variance in mechanical properties similar to that explained by pQCT bone cross-sectional geometry measurements and DXA measurements. CONCLUSIONS: We found that there was a close association between geometry and mechanical properties regardless of the imaging modality (MRI or pQCT) used.
UNLABELLED: We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were significantly associated with bone's mechanical properties. However, cortical density assessed by pQCT was not associated with mechanical properties. INTRODUCTION: The primary objective of this study was to determine the contribution of cross-sectional geometry (by MRI and pQCT) and density (by pQCT and DXA) to mechanical properties of the human cadaveric tibia. METHODS: We assessed 20 human cadaveric tibiae. Bone cross-sectional geometry variables (total area, cortical area, and section modulus) were measured with MRI and pQCT. Cortical density and areal BMD were measured with pQCT and DXA, respectively. The specimens were tested to failure in a four-point bending apparatus. Coefficients of determination between imaging variables of interest and mechanical properties were determined. RESULTS: Cross-sectional geometry measurements from MRI and pQCT were strongly correlated with bone mechanical properties (r(2) range from 0.55 to 0.85). Bone cross-sectional geometry measured by MRI explained a proportion of variance in mechanical properties similar to that explained by pQCT bone cross-sectional geometry measurements and DXA measurements. CONCLUSIONS: We found that there was a close association between geometry and mechanical properties regardless of the imaging modality (MRI or pQCT) used.
Authors: W Högler; C J R Blimkie; C T Cowell; A F Kemp; J Briody; P Wiebe; N Farpour-Lambert; C S Duncan; H J Woodhead Journal: Bone Date: 2003-11 Impact factor: 4.398
Authors: S L Manske; T Liu-Ambrose; P M de Bakker; D Liu; S Kontulainen; P Guy; T R Oxland; H A McKay Journal: Osteoporos Int Date: 2006-07-18 Impact factor: 4.507
Authors: C R Russo; F Lauretani; S Bandinelli; B Bartali; A Di Iorio; S Volpato; J M Guralnik; T Harris; L Ferrucci Journal: Osteoporos Int Date: 2003-06-24 Impact factor: 4.507
Authors: Anniek M Terpstra; Heidi J Kalkwarf; Justine Shults; Babette S Zemel; Rachel J Wetzsteon; Bethany J Foster; C Frederic Strife; Debbie L Foerster; Mary B Leonard Journal: J Am Soc Nephrol Date: 2012-01-26 Impact factor: 10.121
Authors: Kyle K Nishiyama; Adi Cohen; Polly Young; Ji Wang; Joan M Lappe; X Edward Guo; David W Dempster; Robert R Recker; Elizabeth Shane Journal: J Clin Endocrinol Metab Date: 2014-03-31 Impact factor: 5.958
Authors: Amy D DiVasta; Henry A Feldman; Jennifer M O'Donnell; Jin Long; Mary B Leonard; Catherine M Gordon Journal: J Adolesc Health Date: 2019-06-18 Impact factor: 5.012
Authors: Joshua F Baker; Megan Morales; Mohammed Qatanani; Andrew Cucchiara; Eleni Nackos; Mitchell A Lazar; Karen Teff; Joan Marie von Feldt Journal: J Rheumatol Date: 2011-09-01 Impact factor: 4.666
Authors: A Tsampalieros; M K Berkenstock; B S Zemel; L Griffin; J Shults; J M Burnham; R N Baldassano; M B Leonard Journal: Osteoporos Int Date: 2014-04-24 Impact factor: 4.507
Authors: Dale Y Lee; Rachel J Wetzsteon; Babette S Zemel; Justine Shults; Jason M Organ; Bethany J Foster; Rita M Herskovitz; Debbie L Foerster; Mary B Leonard Journal: J Bone Miner Res Date: 2015-03 Impact factor: 6.741
Authors: Mary B Leonard; Babette S Zemel; Brian H Wrotniak; Sarah B Klieger; Justine Shults; Virginia A Stallings; Nicolas Stettler Journal: Bone Date: 2014-12-10 Impact factor: 4.398
Authors: Vincent Lo Re; Kenneth Lynn; Emily R Stumm; Jin Long; Melissa S Nezamzadeh; Joshua F Baker; Andrew N Hoofnagle; Angela J Kapalko; Karam Mounzer; Babette S Zemel; Pablo Tebas; Jay R Kostman; Mary B Leonard Journal: J Infect Dis Date: 2015-03-09 Impact factor: 5.226