Literature DB >> 1726888

The enzymology of proinsulin conversion.

J C Hutton1, C J Rhodes.   

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Year:  1991        PMID： 1726888     DOI： 10.1007/bf02989879

Source DB:  PubMed          Journal:  Cell Biophys        ISSN： 0163-4992


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  16 in total

1.  Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10).

Authors:  J C Hutton; H W Davidson; M Peshavaria
Journal:  Biochem J       Date:  1987-06-01       Impact factor: 3.857

2.  The role of paired basic amino acids in mediating proteolytic cleavage of prosomatostatin. Analysis using site-directed mutagenesis.

Authors:  T J Stoller; D Shields
Journal:  J Biol Chem       Date:  1989-04-25       Impact factor: 5.157

3.  Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.

Authors:  H W Davidson; C J Rhodes; J C Hutton
Journal:  Nature       Date:  1988-05-05       Impact factor: 49.962

4.  Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate.

Authors:  J C Hutton; E J Penn; M Peshavaria
Journal:  Biochem J       Date:  1983-02-15       Impact factor: 3.857

5.  Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin.

Authors:  K Docherty; C J Rhodes; N A Taylor; K I Shennan; J C Hutton
Journal:  J Biol Chem       Date:  1989-11-05       Impact factor: 5.157

6.  NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition.

Authors:  M A Weiss; B H Frank; I Khait; A Pekar; R Heiney; S E Shoelson; L J Neuringer
Journal:  Biochemistry       Date:  1990-09-11       Impact factor: 3.162

7.  An in vivo characterization of the cleavage site specificity of the insulin cell prohormone processing enzymes.

Authors:  B A Thorne; G Thomas
Journal:  J Biol Chem       Date:  1990-05-25       Impact factor: 5.157

8.  The internal pH and membrane potential of the insulin-secretory granule.

Authors:  J C Hutton
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

9.  Biosynthesis and posttranslational processing of site-directed endoproteolytic cleavage mutants of pro-neuropeptide Y in mouse pituitary cells.

Authors:  I M Dickerson; J E Dixon; R E Mains
Journal:  J Biol Chem       Date:  1990-02-15       Impact factor: 5.157

10.  Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.

Authors:  L Orci; M Ravazzola; M Amherdt; O Madsen; A Perrelet; J D Vassalli; R G Anderson
Journal:  J Cell Biol       Date:  1986-12       Impact factor: 10.539
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