Literature DB >> 17268635

C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors.

Vanessa Faugeroux1, Yves Génisson, Nathalie Andrieu-Abadie, Sandra Colié, Thierry Levade, Michel Baltas.   

Abstract

The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.

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Year:  2006        PMID： 17268635     DOI： 10.1039/b613460b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.

Authors:  Jae Chul Lee; Subhashree Francis; Dinah Dutta; Vijayalaxmi Gupta; Yan Yang; Jin-Yi Zhu; Joseph S Tash; Ernst Schönbrunn; Gunda I Georg
Journal:  J Org Chem       Date:  2012-03-20       Impact factor: 4.354

2.  Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.

Authors:  Amar Ghisaidoobe; Pieter Bikker; Arjan C J de Bruijn; Frithjof D Godschalk; Eva Rogaar; Marieke C Guijt; Peter Hagens; Jerre M Halma; Steven M Van't Hart; Stijn B Luitjens; Vincent H S van Rixel; Mark Wijzenbroek; Thor Zweegers; Wilma E Donker-Koopman; Anneke Strijland; Rolf Boot; Gijs van der Marel; Herman S Overkleeft; Johannes M F G Aerts; Richard J B H N van den Berg
Journal:  ACS Med Chem Lett       Date:  2010-12-02       Impact factor: 4.345

3.  Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.

Authors:  Xingxian Gu; Vijayalaxmi Gupta; Yan Yang; Jin-Yi Zhu; Erick J Carlson; Carolyn Kingsley; Joseph S Tash; Ernst Schönbrunn; Jon Hawkinson; Gunda I Georg
Journal:  ChemMedChem       Date:  2017-11-24       Impact factor: 3.466
  3 in total

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