Literature DB >> 17268535

Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery.

I A Khalil1, K Kogure, S Futaki, S Hama, H Akita, M Ueno, H Kishida, M Kudoh, Y Mishina, K Kataoka, M Yamada, H Harashima.   

Abstract

This study describes a multifunctional envelope-type nano device (MEND) that mimics an envelope-type virus based on a novel packaging strategy. MEND particles contain a DNA core packaged into a lipid envelope modified with an octaarginine peptide. The peptide mediates internalization via macropinocytosis, which avoids lysosomal degradation. MEND-mediated transfection of a luciferase expression plasmid achieved comparable efficiency to adenovirus-mediated transfection, with lower associated cytotoxicity. Furthermore, topical application of MEND particles containing constitutively active bone morphogenetic protein (BMP) type IA receptor (caBmpr1a) gene had a significant impact on hair growth in vivo. These data demonstrate that MEND is a promising non-viral gene delivery system that may provide superior results to existing non-viral gene delivery technologies.

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Year:  2007        PMID： 17268535      PMCID： PMC1847622          DOI： 10.1038/sj.gt.3302910

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  35 in total

1.  Biological barriers to cellular delivery of lipid-based DNA carriers.

Authors: 
Journal:  Adv Drug Deliv Rev       Date:  1999-08-20       Impact factor: 15.470

2.  Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems.

Authors:  Susumu Hama; Hidetaka Akita; Rie Ito; Hiroyuki Mizuguchi; Takao Hayakawa; Hideyoshi Harashima
Journal:  Mol Ther       Date:  2005-12-20       Impact factor: 11.454

3.  Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus.

Authors:  M A Zanta; P Belguise-Valladier; J P Behr
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205

4.  Stearylated arginine-rich peptides: a new class of transfection systems.

Authors:  S Futaki; W Ohashi; T Suzuki; M Niwa; S Tanaka; K Ueda; H Harashima; Y Sugiura
Journal:  Bioconjug Chem       Date:  2001 Nov-Dec       Impact factor: 4.774

5.  A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.

Authors:  Rumiko Moriguchi; Kentaro Kogure; Hidetaka Akita; Shiroh Futaki; Makoto Miyagishi; Kazunari Taira; Hideyoshi Harashima
Journal:  Int J Pharm       Date:  2005-09-14       Impact factor: 5.875

6.  Cationic TAT peptide transduction domain enters cells by macropinocytosis.

Authors:  Ian M Kaplan; Jehangir S Wadia; Steven F Dowdy
Journal:  J Control Release       Date:  2005-01-20       Impact factor: 9.776

Review 7.  The emergence of clathrin-independent pinocytic pathways.

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Journal:  Curr Opin Cell Biol       Date:  1995-08       Impact factor: 8.382

8.  Cellular and molecular barriers to gene transfer by a cationic lipid.

Authors:  J Zabner; A J Fasbender; T Moninger; K A Poellinger; M J Welsh
Journal:  J Biol Chem       Date:  1995-08-11       Impact factor: 5.157

9.  Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation.

Authors:  I A Khalil; S Futaki; M Niwa; Y Baba; N Kaji; H Kamiya; H Harashima
Journal:  Gene Ther       Date:  2004-04       Impact factor: 5.250

10.  Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.

Authors:  Krzysztof Kobielak; H Amalia Pasolli; Laura Alonso; Lisa Polak; Elaine Fuchs
Journal:  J Cell Biol       Date:  2003-11-10       Impact factor: 10.539
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  34 in total

Review 1.  Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment.

Authors:  Ayman El-Sayed; Shiroh Futaki; Hideyoshi Harashima
Journal:  AAPS J       Date:  2009-01-06       Impact factor: 4.009

2.  Nanomaterials as Non-viral siRNA Delivery Agents for Cancer Therapy.

Authors:  Sanjay Singh
Journal:  Bioimpacts       Date:  2013-01-14

3.  An amino acid-based amphoteric liposomal delivery system for systemic administration of siRNA.

Authors:  Roger C Adami; Shaguna Seth; Pierrot Harvie; Rachel Johns; Renata Fam; Kathy Fosnaugh; Tianying Zhu; Ken Farber; Michael McCutcheon; Thomas T Goodman; Yan Liu; Yan Chen; Erin Kwang; Michael V Templin; Greg Severson; Tod Brown; Narendra Vaish; Feng Chen; Patrick Charmley; Barry Polisky; Michael E Houston
Journal:  Mol Ther       Date:  2011-04-19       Impact factor: 11.454

4.  Octa-arginine-modified pegylated liposomal doxorubicin: an effective treatment strategy for non-small cell lung cancer.

Authors:  Swati Biswas; Pranali P Deshpande; Federico Perche; Namita S Dodwadkar; Shailendra D Sane; Vladimir P Torchilin
Journal:  Cancer Lett       Date:  2013-02-16       Impact factor: 8.679

5.  Bleomycin in octaarginine-modified fusogenic liposomes results in improved tumor growth inhibition.

Authors:  Alexander Koshkaryev; Aleksandr Piroyan; Vladimir P Torchilin
Journal:  Cancer Lett       Date:  2012-06-25       Impact factor: 8.679

6.  A peptide-based vector for efficient gene transfer in vitro and in vivo.

Authors:  Taavi Lehto; Oscar E Simonson; Imre Mäger; Kariem Ezzat; Helena Sork; Dana-Maria Copolovici; Joana R Viola; Eman M Zaghloul; Per Lundin; Pedro M D Moreno; Maarja Mäe; Nikita Oskolkov; Julia Suhorutšenko; C I Edvard Smith; Samir E L Andaloussi
Journal:  Mol Ther       Date:  2011-02-22       Impact factor: 11.454

7.  Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus.

Authors:  Hidetaka Akita; Kaoru Enoto; Tomoya Masuda; Hiroyuki Mizuguchi; Tomomi Tani; Hideyoshi Harashima
Journal:  Mol Ther       Date:  2010-03-09       Impact factor: 11.454

8.  Self-assembling peptide-lipoplexes for substrate-mediated gene delivery.

Authors:  Jennifer C Rea; Romie F Gibly; Annelise E Barron; Lonnie D Shea
Journal:  Acta Biomater       Date:  2008-10-21       Impact factor: 8.947

9.  Recent developments in peptide-based nucleic acid delivery.

Authors:  Sandra Veldhoen; Sandra D Laufer; Tobias Restle
Journal:  Int J Mol Sci       Date:  2008-07-16       Impact factor: 6.208

Review 10.  Peptide-mediated cellular delivery of oligonucleotide-based therapeutics in vitro: quantitative evaluation of overall efficacy employing easy to handle reporter systems.

Authors:  S D Laufer; T Restle
Journal:  Curr Pharm Des       Date:  2008       Impact factor: 3.116
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