Literature DB >> 17268067

Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis.

Kumiko Horiuchi1, Sumiko Shiota, Teruo Kuroda, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya.   

Abstract

We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.

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Year:  2007        PMID： 17268067     DOI： 10.1248/bpb.30.287

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  12 in total

1.  Carnosic acid is an efflux pumps modulator by dissipation of the membrane potential in Enterococcus faecalis and Staphylococcus aureus.

Authors:  Adriana M Ojeda-Sana; Victoria Repetto; Silvia Moreno
Journal:  World J Microbiol Biotechnol       Date:  2012-09-08       Impact factor: 3.312

2.  Isolation of a new quinic acid derivative and its antibacterial modulating activity.

Authors:  A R Gohari; S Saeidnia; K Mollazadeh; N Yassa; M Malmir; A R Shahverdi
Journal:  Daru       Date:  2010       Impact factor: 3.117

Review 3.  Carnosol: a phenolic diterpene with cancer chemopreventive potential.

Authors:  Kyung-Soo Chun; Juthika Kundu; In Gyeong Chae; Joydeb Kumar Kundu
Journal:  J Cancer Prev       Date:  2014-06

4.  Synergistic effect of Thymbra spicata L. extracts with antibiotics against multidrug- resistant Staphylococcus aureus and Klebsiella pneumoniae strains.

Authors:  Mohammad F Haroun; Rawaa S Al-Kayali
Journal:  Iran J Basic Med Sci       Date:  2016-11       Impact factor: 2.699

5.  Pharmacological properties of Salvia officinalis and its components.

Authors:  Ahmad Ghorbani; Mahdi Esmaeilizadeh
Journal:  J Tradit Complement Med       Date:  2017-01-13

6.  Anti-Campylobacter activities and resistance mechanisms of natural phenolic compounds in Campylobacter.

Authors:  Anja Klančnik; Sonja Smole Možina; Qijing Zhang
Journal:  PLoS One       Date:  2012-12-17       Impact factor: 3.240

7.  Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

Authors:  Lai Wah Chan; Emily L C Cheah; Constance L L Saw; Wanyu Weng; Paul W S Heng
Journal:  Chin Med       Date:  2008-11-28       Impact factor: 5.455

8.  Cytotoxic, antioxidant and antimicrobial activities and phenolic contents of eleven salvia species from iran.

Authors:  Omidreza Firuzi; Ramin Miri; Mojtaba Asadollahi; Saba Eslami; Amir Reza Jassbi
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

9.  In Vitro Antibacterial and Antibiotic Resistance Modifying Effect of Bioactive Plant Extracts on Methicillin-Resistant Staphylococcus epidermidis.

Authors:  Romana Chovanová; Mária Mikulášová; Stefánia Vaverková
Journal:  Int J Microbiol       Date:  2013-10-10

10.  Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2.

Authors:  Li Wang; Yujuan Zhang; Kangdong Liu; Hanyong Chen; Ran Yang; Xiaoli Ma; Hong-Gyum Kim; Ann M Bode; Dong Joon Kim; Zigang Dong
Journal:  Oncotarget       Date:  2018-02-06
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