Literature DB >> 17267503

New natural intergenotypic (2/5) recombinant of hepatitis C virus.

Florence Legrand-Abravanel1, Julie Claudinon, Florence Nicot, Martine Dubois, Sabine Chapuy-Regaud, Karine Sandres-Saune, Christophe Pasquier, Jacques Izopet.   

Abstract

A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.

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Year:  2007        PMID： 17267503      PMCID： PMC1866139          DOI： 10.1128/JVI.02639-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

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8.  Genetic diversity of HCV genotype 2 strains in south western France.

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9.  Multiple recombinants in two dengue virus, serotype-2 isolates from patients from Oaxaca, Mexico.

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