Literature DB >> 17266925

Trehalose effects on alpha-crystallin aggregates.

Francesco Attanasio1, Claudia Cascio, Salvatore Fisichella, Vincenzo Giuseppe Nicoletti, Bruno Pignataro, Anna Savarino, Enrico Rizzarelli.   

Abstract

alpha-Crystallin in its native state is a large, heterogeneous, low-molecular weight (LMW) aggregate that under certain conditions may progressively became part of insoluble high-molecular weight (HMW) systems. These systems are supposed to play a relevant role in eye lens opacification and vision impairment. In this paper, we report the effects of trehalose on alpha-crystallin aggregates. The role of trehalose in alpha-crystallin stress tolerance, chaperone activity and thermal stability is studied. The results show that trehalose stabilizes the alpha-crystallin native structure, inhibits alpha-crystallin aggregation, and disaggregates preformed LMW systems not affecting its chaperone activity.

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Year:  2007        PMID： 17266925     DOI： 10.1016/j.bbrc.2007.01.061

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Effect of trehalose on the properties of mutant {gamma}PKC, which causes spinocerebellar ataxia type 14, in neuronal cell lines and cultured Purkinje cells.

Authors:  Takahiro Seki; Nana Abe-Seki; Takahiro Kikawada; Hideyuki Takahashi; Kazuhiro Yamamoto; Naoko Adachi; Shigeru Tanaka; Izumi Hide; Naoaki Saito; Norio Sakai
Journal:  J Biol Chem       Date:  2010-08-12       Impact factor: 5.157

2.  Trehalose-Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis.

Authors:  Alessia Filippone; Irene Paterniti; Irina Naletova; Valentina Greco; Sebastiano Sciuto; Emanuela Esposito; Salvatore Cuzzocrea; Enrico Rizzarelli
Journal:  Cell Mol Neurobiol       Date:  2022-09-19       Impact factor: 4.231

Review 3.  Trehalose and trehalose-based polymers for environmentally benign, biocompatible and bioactive materials.

Authors:  Naozumi Teramoto; Navzer D Sachinvala; Mitsuhiro Shibata
Journal:  Molecules       Date:  2008-08-21       Impact factor: 4.411

4.  A native chemical chaperone in the human eye lens.

Authors:  Eugene Serebryany; Sourav Chowdhury; Christopher N Woods; David C Thorn; Nicki E Watson; Arthur A McClelland; Rachel E Klevit; Eugene I Shakhnovich
Journal:  Elife       Date:  2022-06-20       Impact factor: 8.713

Review 5.  Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease?

Authors:  Giuseppe Di Natale; Giuseppina Sabatino; Michele Francesco Maria Sciacca; Rita Tosto; Danilo Milardi; Giuseppe Pappalardo
Journal:  Molecules       Date:  2022-08-09       Impact factor: 4.927

6.  Glass transition temperature of dried lens tissue pretreated with trehalose, maltose, or cyclic tetrasaccharide.

Authors:  Tetsuhiro Kawata; Toshihiko Matsuo; Tetsuya Uchida
Journal:  Springerplus       Date:  2014-06-25
  6 in total

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