Literature DB >> 17264921

Chemical double-mutant cycles: dissecting non-covalent interactions.

Scott L Cockroft1, Christopher A Hunter.   

Abstract

Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.

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Year:  2006        PMID： 17264921     DOI： 10.1039/b603842p

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  41 in total

1.  Mutual modulation between membrane-embedded receptor clustering and ligand binding in lipid membranes.

Authors:  Salvador Tomas; Lilia Milanesi
Journal:  Nat Chem       Date:  2010-11-07       Impact factor: 24.427

2.  Orthogonal dipolar interactions between amide carbonyl groups.

Authors:  Felix R Fischer; Peter A Wood; Frank H Allen; François Diederich
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-03       Impact factor: 11.205

3.  How much do van der Waals dispersion forces contribute to molecular recognition in solution?

Authors:  Lixu Yang; Catherine Adam; Gary S Nichol; Scott L Cockroft
Journal:  Nat Chem       Date:  2013-10-20       Impact factor: 24.427

4.  A Chalcogen-Bonding Cascade Switch for Planarizable Push-Pull Probes.

Authors:  Mariano Macchione; Antoine Goujon; Karolina Strakova; Heorhii V Humeniuk; Giuseppe Licari; Emad Tajkhorshid; Naomi Sakai; Stefan Matile
Journal:  Angew Chem Int Ed Engl       Date:  2019-09-20       Impact factor: 15.336

Review 5.  The Cation-π Interaction in Small-Molecule Catalysis.

Authors:  C Rose Kennedy; Song Lin; Eric N Jacobsen
Journal:  Angew Chem Int Ed Engl       Date:  2016-06-22       Impact factor: 15.336

6.  Hydrogen Bonding of 1,2-Azaborines in the Binding Cavity of T4 Lysozyme Mutants: Structures and Thermodynamics.

Authors:  Hyelee Lee; Marcus Fischer; Brian K Shoichet; Shih-Yuan Liu
Journal:  J Am Chem Soc       Date:  2016-09-12       Impact factor: 15.419

7.  Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis.

Authors:  Manuel Orlandi; Jaime A S Coelho; Margaret J Hilton; F Dean Toste; Matthew S Sigman
Journal:  J Am Chem Soc       Date:  2017-05-11       Impact factor: 15.419

8.  Water mediated ligand functional group cooperativity: the contribution of a methyl group to binding affinity is enhanced by a COO(-) group through changes in the structure and thermodynamics of the hydration waters of ligand-thermolysin complexes.

Authors:  Nader N Nasief; Hongwei Tan; Jing Kong; David Hangauer
Journal:  J Med Chem       Date:  2012-09-19       Impact factor: 7.446

9.  DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein-protein interactions.

Authors:  Dennis M Krüger; Holger Gohlke
Journal:  Nucleic Acids Res       Date:  2010-05-28       Impact factor: 16.971

10.  Limiting assumptions in molecular modeling: electrostatics.

Authors:  Garland R Marshall
Journal:  J Comput Aided Mol Des       Date:  2013-01-26       Impact factor: 3.686
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