Literature DB >> 17262167

AID in antibody perfection.

A C Vallur1, M Yabuki, E D Larson, N Maizels.   

Abstract

Expressed immunoglobulin (Ig) genes undergo alterations in sequence and genomic structure in order to optimize antibody function. A single B cell-specific factor, activation-induced deaminase (AID), initiates these changes by deamination of cytosine to uracil. Uracil in DNA is encountered commonly, and conserved pathways are responsible for its faithful repair. However, at the Ig loci of B cells, AID-initiated damage is processed to produce three distinct outcomes: somatic hypermutation, class switch recombination and gene conversion. This review focuses on the role of AID in Ig gene diversification, emphasizing how AID functions within the mechanism of the Ig gene diversification pathway; and highlights open questions for future research, particularly the most provocative current question: what makes a gene a target for AID-initiated mutagenesis?

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17262167     DOI： 10.1007/s00018-007-6434-2

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  6 in total

Review 1.  Diversity of Immunoglobulin (Ig) Isotypes and the Role of Activation-Induced Cytidine Deaminase (AID) in Fish.

Authors:  Bhakti Patel; Rajanya Banerjee; Mrinal Samanta; Surajit Das
Journal:  Mol Biotechnol       Date:  2018-06       Impact factor: 2.695

2.  Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions.

Authors:  Aarthy C Vallur; Nancy Maizels
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-21       Impact factor: 11.205

3.  Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation.

Authors:  Silvia Schanz; Dennis Castor; Franziska Fischer; Josef Jiricny
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-23       Impact factor: 11.205

4.  Repression of human activation induced cytidine deaminase by miR-93 and miR-155.

Authors:  Glen M Borchert; Nathaniel W Holton; Erik D Larson
Journal:  BMC Cancer       Date:  2011-08-10       Impact factor: 4.430

5.  High-fidelity correction of genomic uracil by human mismatch repair activities.

Authors:  Erik D Larson; David W Bednarski; Nancy Maizels
Journal:  BMC Mol Biol       Date:  2008-10-27       Impact factor: 2.946

6.  Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.

Authors:  Rajendra Prasad; Matthew J Longley; Farida S Sharief; Esther W Hou; William C Copeland; Samuel H Wilson
Journal:  Nucleic Acids Res       Date:  2009-02-02       Impact factor: 16.971
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.