Literature DB >> 17260170

Dopamine transporter immunoreactivity in peripheral blood lymphocytes discriminates Parkinson's disease from essential tremor.

C Pellicano1, F R Buttarelli, A Circella, D Tiple, M Giovannelli, D Benincasa, C Colosimo, F E Pontieri.   

Abstract

Peripheral blood lymphocytes (PBL) provide a model to study the changes of neurotransmitter-receptor systems in neurodegenerative disorders, including Parkinson's disease (PD). In this study, densitometric analysis was applied to measure dopamine transporter (DAT) immunoreactivity in PBL from dopaminergic drug-free patients suffering PD or essential tremor (ET) with respect to healthy subjects. The results showed a significant reduction of DAT immunoreactivity in PBL in PD but not in ET. These finding suggests that DAT immunoreactivity in PBL may discriminate between PD and ET in the early clinical stages.

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Year:  2007        PMID： 17260170     DOI： 10.1007/s00702-006-0623-2

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.850


  24 in total

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Journal:  Brain Res Mol Brain Res       Date:  1996-02

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Journal:  Arch Neurol       Date:  2000-02

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Journal:  Neurology       Date:  1967-05       Impact factor: 9.910

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Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-03       Impact factor: 10.154

5.  Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease.

Authors:  J N Joyce; G Smutzer; C J Whitty; A Myers; M J Bannon
Journal:  Mov Disord       Date:  1997-11       Impact factor: 10.338

Review 6.  Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee.

Authors:  G Deuschl; P Bain; M Brin
Journal:  Mov Disord       Date:  1998       Impact factor: 10.338

7.  Dopaminergic deficit in amyotrophic lateral sclerosis assessed with [I-123] IPT single photon emission computed tomography.

Authors:  G D Borasio; R Linke; J Schwarz; V Schlamp; A Abel; P D Mozley; K Tatsch
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-08       Impact factor: 10.154

8.  Altered lymphocyte acetylcholinesterase activity in patients with senile dementia.

Authors:  E Bartha; J Szelényi; K Szilágyi; V Venter; N T Thu Ha; P Páldi-Haris; S Hollán
Journal:  Neurosci Lett       Date:  1987-08-18       Impact factor: 3.046

9.  Diminution of dopaminergic neurons in the substantia nigra of sporadic amyotrophic lateral sclerosis.

Authors:  S Kato; M Oda; H Tanabe
Journal:  Neuropathol Appl Neurobiol       Date:  1993-08       Impact factor: 8.090

10.  Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease.

Authors:  Y Nagai; S Ueno; Y Saeki; F Soga; M Hirano; T Yanagihara
Journal:  Neurology       Date:  1996-03       Impact factor: 9.910
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  5 in total

1.  Fine-mapping reveals novel alternative splicing of the dopamine transporter.

Authors:  Michael E Talkowski; Kathleen L McCann; Michael Chen; Lora McClain; Mikhil Bamne; Joel Wood; Kodavali V Chowdari; Annie Watson; Konasale M Prasad; George Kirov; Lyudmilla Georgieva; Draga Toncheva; Hader Mansour; David A Lewis; Michael Owen; Michael O'Donovan; Panagiotis Papasaikas; Patrick Sullivan; Douglas Ruderfer; Jeffrey K Yao; Sherry Leonard; Pramod Thomas; Fabio Miyajima; John Quinn; A Javier Lopez; Vishwajit L Nimgaonkar
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2010-10-18       Impact factor: 3.568

2.  Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells.

Authors:  Brendan S Beikmann; Ian D Tomlinson; Sandra J Rosenthal; Anne Milasincic Andrews
Journal:  ACS Chem Neurosci       Date:  2012-10-22       Impact factor: 4.418

3.  Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy.

Authors:  Francesca R Buttarelli; Annapia Circella; Clelia Pellicano; Dorina Tiple; Morena Giovannelli; Carlo Colosimo; Francesco E Pontieri
Journal:  J Neural Transm (Vienna)       Date:  2008-12-17       Impact factor: 3.575

4.  The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders.

Authors:  Francesca R Buttarelli; Alessandra Fanciulli; Clelia Pellicano; Francesco E Pontieri
Journal:  Curr Neuropharmacol       Date:  2011-06       Impact factor: 7.363

Review 5.  Development of early diagnosis of Parkinson's disease: Illusion or reality?

Authors:  Michael Ugrumov
Journal:  CNS Neurosci Ther       Date:  2020-06-29       Impact factor: 7.035
  5 in total

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