| Literature DB >> 17259977 |
Assaf A Gilad1, Michael T McMahon, Piotr Walczak, Paul T Winnard, Venu Raman, Hanneke W M van Laarhoven, Cynthia M Skoglund, Jeff W M Bulte, Peter C M van Zijl.
Abstract
Existing magnetic resonance reporter genes all rely on the presence of (super)paramagnetic substances and employ water relaxation to gain contrast. We designed a nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters expressing artificial proteins with frequency-selective contrast. This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off.Entities:
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Year: 2007 PMID： 17259977 DOI： 10.1038/nbt1277
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908