Literature DB >> 17259342

Roles of Aurora kinases in mitosis and tumorigenesis.

Jingyan Fu1, Minglei Bian, Qing Jiang, Chuanmao Zhang.   

Abstract

Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis.

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Year:  2007        PMID： 17259342     DOI： 10.1158/1541-7786.MCR-06-0208

Source DB:  PubMed          Journal:  Mol Cancer Res        ISSN： 1541-7786            Impact factor:   5.852


  220 in total

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Authors:  Yi-Fong Chen; Yi-Chien Lin; Susan L Morris-Natschke; Chen-Fang Wei; Ting-Chen Shen; Hui-Yi Lin; Mei-Hua Hsu; Li-Chen Chou; Yu Zhao; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Br J Pharmacol       Date:  2015-01-13       Impact factor: 8.739

2.  A cell-based assay for screening spindle checkpoint inhibitors.

Authors:  Zhen Hua Wu; Long Yu Hu; Da Qian Xu; Xiaotong Li
Journal:  Assay Drug Dev Technol       Date:  2012-02-21       Impact factor: 1.738

3.  An integrated pharmacokinetic-pharmacodynamic model for an Aurora kinase inhibitor.

Authors:  Hiroko Kamei; Robert C Jackson; Daniella Zheleva; Fordyce A Davidson
Journal:  J Pharmacokinet Pharmacodyn       Date:  2010-08-08       Impact factor: 2.745

Review 4.  Aurora kinase inhibitors as anticancer molecules.

Authors:  Hiroshi Katayama; Subrata Sen
Journal:  Biochim Biophys Acta       Date:  2010-09-20

5.  Bioorthogonal imaging of aurora kinase A in live cells.

Authors:  Katherine S Yang; Ghyslain Budin; Thomas Reiner; Claudio Vinegoni; Ralph Weissleder
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-29       Impact factor: 15.336

Review 6.  Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins.

Authors:  Nana Zheng; Zhiwei Wang; Wenyi Wei
Journal:  Int J Biochem Cell Biol       Date:  2016-02-06       Impact factor: 5.085

7.  A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.

Authors:  Qiaohua Zhu; Meihua Luo; Chengyu Zhou; Zhiwei Zhou; Zhixu He; Xinfa Yu; Shufeng Zhou
Journal:  Am J Transl Res       Date:  2017-08-15       Impact factor: 4.060

8.  Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.

Authors:  Alberto Maria Luciano; Federica Franciosi; Valentina Lodde; Irene Tessaro; Davide Corbani; Silvia Clotilde Modina; John J Peluso
Journal:  Biol Reprod       Date:  2013-03-07       Impact factor: 4.285

9.  Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.

Authors:  Su-Yeon Lee; Eun-Young Kim; Kyeoung-Hwa Kim; Kyung-Ah Lee
Journal:  Cell Cycle       Date:  2016-10-18       Impact factor: 4.534

Review 10.  Aurora B kinase: a potential drug target for cancer therapy.

Authors:  Azaj Ahmed; Anas Shamsi; Taj Mohammad; Gulam Mustafa Hasan; Asimul Islam; Md Imtaiyaz Hassan
Journal:  J Cancer Res Clin Oncol       Date:  2021-05-28       Impact factor: 4.553
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