Literature DB >> 17259321

Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycle.

Indranil Chatterjee1, Mathias Herrmann, Richard A Proctor, Georg Peters, Barbara C Kahl.   

Abstract

The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC, and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.

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Year:  2007        PMID： 17259321      PMCID： PMC1855812          DOI： 10.1128/JB.01444-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

1.  Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus.

Authors:  L Janzon; S Löfdahl; S Arvidson
Journal:  Mol Gen Genet       Date:  1989-11

2.  sigmaB activity in a Staphylococcus aureus hemB mutant.

Authors:  Maria M Senn; Markus Bischoff; Christof von Eiff; Brigitte Berger-Bächi
Journal:  J Bacteriol       Date:  2005-11       Impact factor: 3.490

Review 3.  Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections.

Authors:  Richard A Proctor; Christof von Eiff; Barbara C Kahl; Karsten Becker; Peter McNamara; Mathias Herrmann; Georg Peters
Journal:  Nat Rev Microbiol       Date:  2006-04       Impact factor: 60.633

4.  Recovery of small colony variants of Staphylococcus aureus following gentamicin bead placement for osteomyelitis.

Authors:  C von Eiff; D Bettin; R A Proctor; B Rolauffs; N Lindner; W Winkelmann; G Peters
Journal:  Clin Infect Dis       Date:  1997-11       Impact factor: 9.079

5.  Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles.

Authors:  Barbara C Kahl; Gunnar Belling; Petra Becker; Indranil Chatterjee; Katrin Wardecki; Karin Hilgert; Ambrose L Cheung; Georg Peters; Mathias Herrmann
Journal:  Infect Immun       Date:  2005-07       Impact factor: 3.441

6.  Transcription of virulence factors in Staphylococcus aureus small-colony variants isolated from cystic fibrosis patients is influenced by SigB.

Authors:  Hélène Moisan; Eric Brouillette; Christian Lebeau Jacob; Philippe Langlois-Bégin; Sophie Michaud; François Malouin
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

7.  Phenotype microarray profiling of Staphylococcus aureus menD and hemB mutants with the small-colony-variant phenotype.

Authors:  Christof von Eiff; Peter McNamara; Karsten Becker; Donna Bates; Xiang-He Lei; Michael Ziman; Barry R Bochner; Georg Peters; Richard A Proctor
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

8.  Staphylocidal action of thrombin-induced platelet microbicidal protein is not solely dependent on transmembrane potential.

Authors:  S P Koo; A S Bayer; H G Sahl; R A Proctor; M R Yeaman
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

9.  Global gene expression in Staphylococcus aureus biofilms.

Authors:  Karen E Beenken; Paul M Dunman; Fionnuala McAleese; Daphne Macapagal; Ellen Murphy; Steven J Projan; Jon S Blevins; Mark S Smeltzer
Journal:  J Bacteriol       Date:  2004-07       Impact factor: 3.490

Review 10.  Variant subpopulations of Staphylococcus aureus as cause of persistent and recurrent infections.

Authors:  R A Proctor; J M Balwit; O Vesga
Journal:  Infect Agents Dis       Date:  1994-12
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  22 in total

1.  Altered growth, pigmentation, and antimicrobial susceptibility properties of Staphylococcus aureus due to loss of the major cold shock gene cspB.

Authors:  Brea D Duval; Anselmo Mathew; Sarah W Satola; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2010-04-05       Impact factor: 5.191

Review 2.  Small colony variants of Staphylococcus aureus--review.

Authors:  O Melter; B Radojevič
Journal:  Folia Microbiol (Praha)       Date:  2011-01-21       Impact factor: 2.099

3.  Characterization of clinical Enterococcus faecalis small-colony variants.

Authors:  Nele Wellinghausen; Indranil Chatterjee; Anja Berger; Andrea Niederfuehr; Richard A Proctor; Barbara C Kahl
Journal:  J Clin Microbiol       Date:  2009-07-15       Impact factor: 5.948

4.  Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.

Authors:  Hoang Anh Nguyen; Olivier Denis; Anne Vergison; Anne Theunis; Paul M Tulkens; Marc J Struelens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

5.  Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus.

Authors:  Tobias Norström; Jonas Lannergård; Diarmaid Hughes
Journal:  Antimicrob Agents Chemother       Date:  2007-10-08       Impact factor: 5.191

6.  Non-spa-typeable clinical Staphylococcus aureus strains are naturally occurring protein A mutants.

Authors:  Cathrin Baum; Bettina Haslinger-Löffler; Henrik Westh; Kit Boye; Georg Peters; Claudia Neumann; Barbara C Kahl
Journal:  J Clin Microbiol       Date:  2009-09-16       Impact factor: 5.948

7.  Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge.

Authors:  Andre Kriegeskorte; Nicola Ivan Lorè; Alessandra Bragonzi; Camilla Riva; Marco Kelkenberg; Karsten Becker; Richard A Proctor; Georg Peters; Barbara C Kahl
Journal:  Antimicrob Agents Chemother       Date:  2015-09-14       Impact factor: 5.191

8.  In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus.

Authors:  Indranil Chatterjee; Andre Kriegeskorte; Andreas Fischer; Susanne Deiwick; Nadine Theimann; Richard A Proctor; Georg Peters; Mathias Herrmann; Barbara C Kahl
Journal:  J Bacteriol       Date:  2007-09-28       Impact factor: 3.490

9.  RpiRc Is a Pleiotropic Effector of Virulence Determinant Synthesis and Attenuates Pathogenicity in Staphylococcus aureus.

Authors:  Rosmarie Gaupp; Jessica Wirf; B Wonnenberg; Tanja Biegel; J Eisenbeis; J Graham; M Herrmann; C Y Lee; C Beisswenger; C Wolz; T Tschernig; M Bischoff; G A Somerville
Journal:  Infect Immun       Date:  2016-06-23       Impact factor: 3.441

10.  The catabolite control protein E (CcpE) affects virulence determinant production and pathogenesis of Staphylococcus aureus.

Authors:  Torsten Hartmann; Grégory Baronian; Nadine Nippe; Meike Voss; Bettina Schulthess; Christiane Wolz; Janina Eisenbeis; Kerstin Schmidt-Hohagen; Rosmarie Gaupp; Cord Sunderkötter; Christoph Beisswenger; Robert Bals; Greg A Somerville; Mathias Herrmann; Virginie Molle; Markus Bischoff
Journal:  J Biol Chem       Date:  2014-09-05       Impact factor: 5.157
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