Literature DB >> 17258357

ELISA IgG concentrations and opsonophagocytic activity following pneumococcal protein D conjugate vaccination and relationship to efficacy against acute otitis media.

Lode Schuerman1, Roman Prymula, Isabelle Henckaerts, Jan Poolman.   

Abstract

We explored the relationship between efficacy against acute otitis media (AOM) and both ELISA anti-polysaccharide IgG geometric mean concentrations (GMCs) and opsonophagocytic (OPA) geometric mean titres (GMTs) following primary and booster vaccination with pneumococcal protein D (Haemophilus influenzae-derived) conjugate vaccine. It was possible to distinguish between the OPA GMTs of low and high efficacy serotypes, however no such distinction was evident for ELISA GMCs. Also, there was a trend towards lower ELISA and OPA serotype-specific responses in subjects who developed AOM compared to controls. We conclude that serotype-specific OPA GMTs are an important endpoint to consider for evaluation of pneumococcal conjugate vaccines with respect to the protective efficacy against AOM (Study ID: 347414/NCT00119743).

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Year:  2006        PMID： 17258357     DOI： 10.1016/j.vaccine.2006.12.008

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  10 in total

1.  Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age.

Authors:  F M Russell; J R Carapetis; R L Burton; J Lin; P V Licciardi; A Balloch; L Tikoduadua; L Waqatakirewa; Y B Cheung; M L K Tang; M H Nahm; E K Mulholland
Journal:  Vaccine       Date:  2010-10-31       Impact factor: 3.641

2.  Aggregation of Streptococcus pneumoniae by a pneumococcal capsular polysaccharide-specific human monoclonal IgM correlates with antibody efficacy in vivo.

Authors:  Kevin Fabrizio; Catherine Manix; Allan J Guimaraes; Joshua D Nosanchuk; Liise-Anne Pirofski
Journal:  Clin Vaccine Immunol       Date:  2010-03-03

3.  A biologically conjugated polysaccharide vaccine delivered by attenuated Salmonella Typhimurium provides protection against challenge of avian pathogenic Escherichia coli O1 infection.

Authors:  Yue Han; Qing Liu; Jie Yi; Kang Liang; Yunan Wei; Qingke Kong
Journal:  Pathog Dis       Date:  2017-11-30       Impact factor: 3.166

4.  Impact of the conjugation method on the immunogenicity of Streptococcus pneumoniae serotype 19F polysaccharide in conjugate vaccines.

Authors:  Jan Poolman; Carl Frasch; Anu Nurkka; Helena Käyhty; Ralph Biemans; Lode Schuerman
Journal:  Clin Vaccine Immunol       Date:  2010-12-01

5.  Serotype-related variation in susceptibility to complement deposition and opsonophagocytosis among clinical isolates of Streptococcus pneumoniae.

Authors:  Merit Melin; Krzysztof Trzciński; Martin Antonio; Seppo Meri; Richard Adegbola; Tarja Kaijalainen; Helena Käyhty; Merja Väkeväinen
Journal:  Infect Immun       Date:  2010-09-20       Impact factor: 3.441

6.  Streptococcus pneumoniae capsular serotype 19F is more resistant to C3 deposition and less sensitive to opsonophagocytosis than serotype 6B.

Authors:  Merit Melin; Hanna Jarva; Lotta Siira; Seppo Meri; Helena Käyhty; Merja Väkeväinen
Journal:  Infect Immun       Date:  2008-12-01       Impact factor: 3.441

Review 7.  Pneumococcal polysaccharide protein D-conjugate vaccine (Synflorix; PHiD-CV).

Authors:  Jamie D Croxtall; Gillian M Keating
Journal:  Paediatr Drugs       Date:  2009       Impact factor: 3.022

8.  Immunogenicity and safety of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) co-administered with DTPa vaccine in Japanese children: A randomized, controlled study.

Authors:  Satoshi Iwata; Naohisa Kawamura; Haruo Kuroki; Yasunobu Tokoeda; Mitsunobu Miyazu; Asayuki Iwai; Tomohiro Oishi; Tomohide Sato; Akari Suyama; Nancy François; Fakrudeen Shafi; Javier Ruiz-Guiñazú; Dorota Borys
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

Review 9.  Methodological criticisms in the evaluation of Pneumococcal Conjugate Vaccine effectiveness.

Authors:  C Trucchi; C Paganino; F Ansaldi
Journal:  J Prev Med Hyg       Date:  2015-08-31

Review 10.  Role of pneumococcal vaccination in prevention of pneumococcal disease among adults in Singapore.

Authors:  Philip Eng; Lean Huat Lim; Chian Min Loo; James Alvin Low; Carol Tan; Eng Kiat Tan; Sin Yew Wong; Sajita Setia
Journal:  Int J Gen Med       Date:  2014-03-31
  10 in total

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