| Literature DB >> 17258205 |
Sven Chlench1, Nigussie Mecha Disassa, Margret Hohberg, Christian Hoffmann, Theresa Pohlkamp, Gabriele Beyer, Mauro Bongrazio, Luis Da Silva-Azevedo, Oliver Baum, Axel Radlach Pries, Andreas Zakrzewicz.
Abstract
Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6dyn/cm(2), 24h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.Entities:
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Year: 2007 PMID： 17258205 DOI： 10.1016/j.febslet.2007.01.028
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124