| Literature DB >> 17257903 |
Shashank Kumar Singh1, Sachin Bhusari, Reena Singh, Ajit Saxena, Dilip Mondhe, Ghulam Nabi Qazi.
Abstract
Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto beta-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel+bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto beta-boswellic acids (10 mg/kg/d) inhibited the Matrigel+bFGF-induced angiogenesis significantly (P<0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).Entities:
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Year: 2006 PMID： 17257903 DOI： 10.1016/j.vph.2006.09.008
Source DB: PubMed Journal: Vascul Pharmacol ISSN： 1537-1891 Impact factor: 5.773