| Literature DB >> 17257888 |
Bingxiu Xiao1, Junming Guo, Donghai Liu, Shun Zhang.
Abstract
Aloe-emodin is a natural anthraquinone compound from the root and rhizome of Rheum palmatum. In this study, KB cells were treated with 2.5, 5, 10, 20, and 40 microM aloe-emodin for 1 to 5 days. The results showed that aloe-emodin inhibited cancer cells in a dose-dependent manner. Treatment with aloe-emodin at 10 to 40 microM resulted in cell cycle arrest at G2/M phase. The alkaline phosphatase (ALP) activity in KB cells increased upon treatment with aloe-emodin when compared to controls. This is one of the first studies to focus on the expression of ALP in human oral carcinomas cells treated with aloe-emodin. These results indicate that aloe-emodin has anti-cancer effect on oral cancer, which may lead to its use in chemotherapy and chemopreventment of oral cancer.Entities:
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Year: 2007 PMID： 17257888 DOI： 10.1016/j.oraloncology.2006.11.002
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337