Literature DB >> 17257865

Two Aspergillus nidulans genes encoding methylenetetrahydrofolate reductases are up-regulated by homocysteine.

Marzena Sieńko1, Renata Natorff, Zbigniew Zieliński, Arkadiusz Hejduk, Andrzej Paszewski.   

Abstract

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate in the synthesis of methionine from homocysteine. We have cloned and characterized two Aspergillus nidulans genes encoding MTHFRs: metA and metF. Mutations in either gene result in methionine requirement; the metA-encoded enzyme is responsible for only 10-15% of total MTHFR activity. These two enzymes belong to different classes of MTHFRs. Mutations in metA but not in the metF gene are suppressed by mutations resulting in enhancement of homocysteine synthesis. The expression of both genes is up-regulated by homocysteine.

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Year:  2006        PMID： 17257865     DOI： 10.1016/j.fgb.2006.12.002

Source DB:  PubMed          Journal:  Fungal Genet Biol        ISSN： 1087-1845            Impact factor:   3.495


  8 in total

1.  Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.

Authors:  Rebecca A Owens; Grainne O'Keeffe; Elizabeth B Smith; Stephen K Dolan; Stephen Hammel; Kevin J Sheridan; David A Fitzpatrick; Thomas M Keane; Gary W Jones; Sean Doyle
Journal:  Eukaryot Cell       Date:  2015-07-06

2.  Methylenetetrahydrofolate reductase activity is involved in the plasma membrane redox system required for pigment biosynthesis in filamentous fungi.

Authors:  Rasmus J N Frandsen; Klaus Selk Albertsen; Peter Stougaard; Jens L Sørensen; Kristian F Nielsen; Stefan Olsson; Henriette Giese
Journal:  Eukaryot Cell       Date:  2010-06-11

Review 3.  The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.

Authors:  Monika Schmoll; Christoph Dattenböck; Nohemí Carreras-Villaseñor; Artemio Mendoza-Mendoza; Doris Tisch; Mario Ivan Alemán; Scott E Baker; Christopher Brown; Mayte Guadalupe Cervantes-Badillo; José Cetz-Chel; Gema Rosa Cristobal-Mondragon; Luis Delaye; Edgardo Ulises Esquivel-Naranjo; Alexa Frischmann; Jose de Jesus Gallardo-Negrete; Monica García-Esquivel; Elida Yazmin Gomez-Rodriguez; David R Greenwood; Miguel Hernández-Oñate; Joanna S Kruszewska; Robert Lawry; Hector M Mora-Montes; Tania Muñoz-Centeno; Maria Fernanda Nieto-Jacobo; Guillermo Nogueira Lopez; Vianey Olmedo-Monfil; Macario Osorio-Concepcion; Sebastian Piłsyk; Kyle R Pomraning; Aroa Rodriguez-Iglesias; Maria Teresa Rosales-Saavedra; J Alejandro Sánchez-Arreguín; Verena Seidl-Seiboth; Alison Stewart; Edith Elena Uresti-Rivera; Chih-Li Wang; Ting-Fang Wang; Susanne Zeilinger; Sergio Casas-Flores; Alfredo Herrera-Estrella
Journal:  Microbiol Mol Biol Rev       Date:  2016-02-10       Impact factor: 11.056

4.  The 2008 update of the Aspergillus nidulans genome annotation: a community effort.

Authors:  Jennifer Russo Wortman; Jane Mabey Gilsenan; Vinita Joardar; Jennifer Deegan; John Clutterbuck; Mikael R Andersen; David Archer; Mojca Bencina; Gerhard Braus; Pedro Coutinho; Hans von Döhren; John Doonan; Arnold J M Driessen; Pawel Durek; Eduardo Espeso; Erzsébet Fekete; Michel Flipphi; Carlos Garcia Estrada; Steven Geysens; Gustavo Goldman; Piet W J de Groot; Kim Hansen; Steven D Harris; Thorsten Heinekamp; Kerstin Helmstaedt; Bernard Henrissat; Gerald Hofmann; Tim Homan; Tetsuya Horio; Hiroyuki Horiuchi; Steve James; Meriel Jones; Levente Karaffa; Zsolt Karányi; Masashi Kato; Nancy Keller; Diane E Kelly; Jan A K W Kiel; Jung-Mi Kim; Ida J van der Klei; Frans M Klis; Andriy Kovalchuk; Nada Krasevec; Christian P Kubicek; Bo Liu; Andrew Maccabe; Vera Meyer; Pete Mirabito; Márton Miskei; Magdalena Mos; Jonathan Mullins; David R Nelson; Jens Nielsen; Berl R Oakley; Stephen A Osmani; Tiina Pakula; Andrzej Paszewski; Ian Paulsen; Sebastian Pilsyk; István Pócsi; Peter J Punt; Arthur F J Ram; Qinghu Ren; Xavier Robellet; Geoff Robson; Bernhard Seiboth; Piet van Solingen; Thomas Specht; Jibin Sun; Naimeh Taheri-Talesh; Norio Takeshita; Dave Ussery; Patricia A vanKuyk; Hans Visser; Peter J I van de Vondervoort; Ronald P de Vries; Jonathan Walton; Xin Xiang; Yi Xiong; An Ping Zeng; Bernd W Brandt; Michael J Cornell; Cees A M J J van den Hondel; Jacob Visser; Stephen G Oliver; Geoffrey Turner
Journal:  Fungal Genet Biol       Date:  2008-12-25       Impact factor: 3.495

5.  Aspergillus nidulans genes encoding reverse transsulfuration enzymes belong to homocysteine regulon.

Authors:  Marzena Sieńko; Renata Natorff; Sylwia Owczarek; Igor Olewiecki; Andrzej Paszewski
Journal:  Curr Genet       Date:  2009-08-15       Impact factor: 3.886

6.  The MET13 methylenetetrahydrofolate reductase gene is essential for infection-related morphogenesis in the rice blast fungus Magnaporthe oryzae.

Authors:  Xia Yan; Yawei Que; Hong Wang; Congcong Wang; Ya Li; Xiaofeng Yue; Zhonghua Ma; Nicholas J Talbot; Zhengyi Wang
Journal:  PLoS One       Date:  2013-10-07       Impact factor: 3.240

7.  A proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatus.

Authors:  Rebecca A Owens; Stephen Hammel; Kevin J Sheridan; Gary W Jones; Sean Doyle
Journal:  PLoS One       Date:  2014-09-08       Impact factor: 3.240

8.  Internalization of the Aspergillus nidulans AstA Transporter into Mitochondria Depends on Growth Conditions, and Affects ATP Levels and Sulfite Oxidase Activity.

Authors:  Sebastian Piłsyk; Adam Mieczkowski; Maciej P Golan; Agata Wawrzyniak; Joanna S Kruszewska
Journal:  Int J Mol Sci       Date:  2020-10-19       Impact factor: 5.923
  8 in total

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