HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. CONCLUSION: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH.
HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. CONCLUSION: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH.
Authors: Elizabeth C Leritz; David H Salat; Victoria J Williams; David M Schnyer; James L Rudolph; Lewis Lipsitz; Bruce Fischl; Regina E McGlinchey; William P Milberg Journal: Neuroimage Date: 2010-10-28 Impact factor: 6.556
Authors: Cyrus A Raji; April J Ho; Neelroop N Parikshak; James T Becker; Oscar L Lopez; Lewis H Kuller; Xue Hua; Alex D Leow; Arthur W Toga; Paul M Thompson Journal: Hum Brain Mapp Date: 2010-03 Impact factor: 5.038
Authors: Christina E Hugenschmidt; Fang-Chi Hsu; Satoru Hayasaka; J Jeffrey Carr; Barry I Freedman; David L Nyenhuis; Jeff D Williamson; Donald W Bowden Journal: J Diabetes Complications Date: 2013-05-07 Impact factor: 2.852
Authors: Jetro J Tuulari; Henry K Karlsson; Olli Antikainen; Jussi Hirvonen; Tam Pham; Paulina Salminen; Mika Helmiö; Riitta Parkkola; Pirjo Nuutila; Lauri Nummenmaa Journal: Hum Brain Mapp Date: 2016-11 Impact factor: 5.038
Authors: R Nick Bryan; Michel Bilello; Christos Davatzikos; Ronald M Lazar; Anne Murray; Karen Horowitz; James Lovato; Michael E Miller; Jeff Williamson; Lenore J Launer Journal: Radiology Date: 2014-04-29 Impact factor: 11.105