Literature DB >> 17256943

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.

Mamoun M Alhamadsheh1, Nadaraj Palaniappan, Suparna Daschouduri, Kevin A Reynolds.   

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Year:  2007        PMID： 17256943      PMCID： PMC2553709          DOI： 10.1021/ja068818t

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  12 in total

1.  Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.

Authors:  T Usui; G Marriott; M Inagaki; G Swarup; H Osada
Journal:  J Biochem       Date:  1999-05       Impact factor: 3.387

2.  Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases.

Authors:  Patrick Caffrey
Journal:  Chembiochem       Date:  2003-07-07       Impact factor: 3.164

3.  Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates.

Authors:  I E Holzbaur; A Ranganathan; I P Thomas; D J Kearney; J A Reather; B A Rudd; J Staunton; P F Leadlay
Journal:  Chem Biol       Date:  2001-04

4.  Cloning and heterologous expression of the epothilone gene cluster.

Authors:  L Tang; S Shah; L Chung; J Carney; L Katz; C Khosla; B Julien
Journal:  Science       Date:  2000-01-28       Impact factor: 47.728

5.  Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.

Authors:  Jiaquan Wu; Toby J Zaleski; Chiara Valenzano; Chaitan Khosla; David E Cane
Journal:  J Am Chem Soc       Date:  2005-12-14       Impact factor: 15.419

6.  Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

Authors:  P R August; L Tang; Y J Yoon; S Ning; R Müller; T W Yu; M Taylor; D Hoffmann; C G Kim; X Zhang; C R Hutchinson; H G Floss
Journal:  Chem Biol       Date:  1998-02

7.  Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.

Authors:  S Fushimi; K Furihata; H Seto
Journal:  J Antibiot (Tokyo)       Date:  1989-07       Impact factor: 2.649

8.  A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.

Authors:  Ralph Reid; Misty Piagentini; Eduardo Rodriguez; Gary Ashley; Nina Viswanathan; John Carney; Daniel V Santi; C Richard Hutchinson; Robert McDaniel
Journal:  Biochemistry       Date:  2003-01-14       Impact factor: 3.162

9.  Studies on new phosphate ester antifungal antibiotics phoslactomycins. I. Taxonomy, fermentation, purification and biological activities.

Authors:  S Fushimi; S Nishikawa; A Shimazu; H Seto
Journal:  J Antibiot (Tokyo)       Date:  1989-07       Impact factor: 2.649

10.  Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa.

Authors:  Hiten M Patel; Junhua Tao; Christopher T Walsh
Journal:  Biochemistry       Date:  2003-09-09       Impact factor: 3.162
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  18 in total

1.  Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene.

Authors:  Shilah A Bonnett; Jonathan R Whicher; Kancharla Papireddy; Galina Florova; Janet L Smith; Kevin A Reynolds
Journal:  Chem Biol       Date:  2013-06-20

2.  Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase.

Authors:  Greg J Dodge; Danialle Ronnow; Richard E Taylor; Janet L Smith
Journal:  ACS Chem Biol       Date:  2018-09-12       Impact factor: 5.100

3.  Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans.

Authors:  Ahmed Khalil; Jessica A Edwards; Chad A Rappleye; Werner Tjarks
Journal:  Bioorg Med Chem       Date:  2014-12-10       Impact factor: 3.641

4.  Crystal structure of the erythromycin polyketide synthase dehydratase.

Authors:  Adrian Keatinge-Clay
Journal:  J Mol Biol       Date:  2008-10-11       Impact factor: 5.469

5.  Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase.

Authors:  Dhara D Shah; Young-Ok You; David E Cane
Journal:  J Am Chem Soc       Date:  2017-09-27       Impact factor: 15.419

Review 6.  Active site comparisons and catalytic mechanisms of the hot dog superfamily.

Authors:  Jason W Labonte; Craig A Townsend
Journal:  Chem Rev       Date:  2012-12-03       Impact factor: 60.622

7.  Generation of novel pikromycin antibiotic products through mutasynthesis.

Authors:  Shuchi Gupta; Venkatraman Lakshmanan; Beom Seok Kim; Robert Fecik; Kevin A Reynolds
Journal:  Chembiochem       Date:  2008-07-02       Impact factor: 3.164

8.  cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme.

Authors:  Nadaraj Palaniappan; Mamoun M Alhamadsheh; Kevin A Reynolds
Journal:  J Am Chem Soc       Date:  2008-08-21       Impact factor: 15.419

9.  Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase.

Authors:  Darren Gay; Young-Ok You; Adrian Keatinge-Clay; David E Cane
Journal:  Biochemistry       Date:  2013-11-25       Impact factor: 3.162

10.  Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins.

Authors:  Mohini S Ghatge; Nadaraj Palaniappan; Ma'moun M Alhamadsheh; Jessica DiBari; Kevin A Reynolds
Journal:  Appl Environ Microbiol       Date:  2009-03-20       Impact factor: 4.792
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