| Literature DB >> 17256910 |
Antoine Fadel1, Nabil Lahrache.
Abstract
Enantiomerically pure (R)-(+)-pipecolic acid was synthesized in four steps and 42% overall yield starting from dihydropyran and (R)-alpha-methylbenzylamine. A general short strategy is also described for preparing (S)-proline (47.5% overall yield) and derivatives.Entities:
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Year: 2007 PMID： 17256910 DOI： 10.1021/jo062382i
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354