Literature DB >> 17256473

Structure-activity relationships of xanthocillin derivatives as thrombopoietin receptor agonist.

Takahiro Yamaguchi1, Yumi Miyake, Atsushi Miyamura, Norihisa Ishiwata, Kuniaki Tatsuta.   

Abstract

Xanthocillin derivatives, which show thrombopoietin receptor agonist activity, were synthesized through our developed method. Bioassay data suggest the importance of alkene geometry, the presence of substituents at the benzene ring that support hydrophobic character, and the moderate size of the molecule. One of the two isonitrile group of the natural product appears to be dispensable.

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Year:  2006        PMID： 17256473     DOI： 10.1038/ja.2006.98

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity.

Authors:  Nicholas Raffa; Tae Hyung Won; Andrew Sukowaty; Kathleen Candor; Chengsen Cui; Saayak Halder; Mingji Dai; Julio A Landero-Figueroa; Frank C Schroeder; Nancy P Keller
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-23       Impact factor: 11.205

2.  Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Authors:  Nicholas C Harris; David A Born; Wenlong Cai; Yaobing Huang; Joelle Martin; Ryan Khalaf; Catherine L Drennan; Wenjun Zhang
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-03       Impact factor: 15.336

3.  Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis.

Authors:  Ines Hübner; Justin A Shapiro; Jörn Hoßmann; Jonas Drechsel; Stephan M Hacker; Philip N Rather; Dietmar H Pieper; William M Wuest; Stephan A Sieber
Journal:  ACS Cent Sci       Date:  2021-01-20       Impact factor: 14.553
  3 in total

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