| Literature DB >> 17256468 |
Satoshi Miyanaga1, Takamasa Obata, Hiroyasu Onaka, Tsuyoshi Fujita, Noriko Saito, Hiroaki Sakurai, Ikuo Saiki, Tamotsu Furumai, Yasuhiro Igarashi.
Abstract
In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.Entities:
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Year: 2006 PMID： 17256468 DOI： 10.1038/ja.2006.93
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649