| Literature DB >> 17254963 |
Abstract
How extracellular signals communicate with the cell cycle is poorly understood. In this issue, two papers address this problem by reporting phosphorylation of the cyclin-dependent kinase inhibitor p27Kip1 on a tyrosine residue by nonreceptor tyrosine kinases, which decreases p27 stability. This new mechanism could explain how cells enter the cell cycle from a quiescent state.Entities:
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Year: 2007 PMID： 17254963 DOI： 10.1016/j.cell.2007.01.006
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582