| Literature DB >> 17254959 |
Abstract
The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.Entities:
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Year: 2007 PMID： 17254959 DOI： 10.1016/j.cell.2007.01.005
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582