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Literature DB >> 17254945

Translational dysregulation by Pateamine A.

Abstract

Pateamine A inhibits translation by preventing proper translational initiation complex formation. In the December issue of Chemistry & Biology, Bordeleau et al. demonstrated that the effects of Patemine A on translation are mediated through the interaction between the RNA helicase eIF4A and mRNA .

Entities: Chemical Gene

Mesh：

Substances：

Year: 2007 PMID： 17254945 PMCID： PMC1803764 DOI： 10.1016/j.chembiol.2007.01.003

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

15 in total

Review 1. eIF4A: the godfather of the DEAD box helicases.

Authors: George W Rogers; Anton A Komar; William C Merrick
Journal: Prog Nucleic Acid Res Mol Biol Date: 2002

2. Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.

Authors: Rachid Mazroui; Rami Sukarieh; Marie-Eve Bordeleau; Randal J Kaufman; Peter Northcote; Junichi Tanaka; Imed Gallouzi; Jerry Pelletier
Journal: Mol Biol Cell Date: 2006-07-26 Impact factor: 4.138

3. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.

Authors: Hsin-Sheng Yang; Aaron P Jansen; Anton A Komar; Xiaojing Zheng; William C Merrick; Sylvain Costes; Stephen J Lockett; Nahum Sonenberg; Nancy H Colburn
Journal: Mol Cell Biol Date: 2003-01 Impact factor: 4.272

4. Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function.

Authors: Tobias von der Haar; John E G McCarthy
Journal: Mol Microbiol Date: 2002-10 Impact factor: 3.501

5. RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation.

Authors: Marie-Eve Bordeleau; Regina Cencic; Lisa Lindqvist; Monika Oberer; Peter Northcote; Gerhard Wagner; Jerry Pelletier
Journal: Chem Biol Date: 2006-12

6. Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.

Authors: Yongjun Dang; Nancy Kedersha; Woon-Kai Low; Daniel Romo; Myriam Gorospe; Randal Kaufman; Paul Anderson; Jun O Liu
Journal: J Biol Chem Date: 2006-09-02 Impact factor: 5.157

7. Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine a: design, synthesis, and activity studies leading to a potent simplified derivative.

Authors: Daniel Romo; Nam Song Choi; Shukun Li; Ingrid Buchler; Zonggao Shi; Jun O Liu
Journal: J Am Chem Soc Date: 2004-09-01 Impact factor: 15.419

8. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.

Authors: Isabel M Palacios; David Gatfield; Daniel St Johnston; Elisa Izaurralde
Journal: Nature Date: 2004-02-19 Impact factor: 49.962

9. The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.

Authors: J Yoder-Hill; A Pause; N Sonenberg; W C Merrick
Journal: J Biol Chem Date: 1993-03-15 Impact factor: 5.157

10. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

Authors: A Pause; N Méthot; Y Svitkin; W C Merrick; N Sonenberg
Journal: EMBO J Date: 1994-03-01 Impact factor: 11.598

5 in total

Translational dysregulation by Pateamine A.

Review 1. eIF4A: the godfather of the DEAD box helicases.

2. Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.

3. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.

4. Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function.

5. RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation.

6. Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.

7. Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine a: design, synthesis, and activity studies leading to a potent simplified derivative.

8. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.

9. The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.

10. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

1. The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication.

Review 2. Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.

Review 3. Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.

4. Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.

Review 5. Targeting stress granules: A novel therapeutic strategy for human diseases.