Literature DB >> 17254787

Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.

Maurizio Botta1, Silvia Armaroli, Daniele Castagnolo, Gabriele Fontana, Paula Pera, Ezio Bombardelli.   

Abstract

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.

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Year:  2007        PMID： 17254787     DOI： 10.1016/j.bmcl.2006.12.101

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.

Authors:  Daniele Castagnolo; Lorenzo Contemori; Giorgio Maccari; Stanislava I Avramova; Annalisa Neri; Gianpietro Sgaragli; Maurizio Botta
Journal:  ACS Med Chem Lett       Date:  2010-07-15       Impact factor: 4.345

2.  New imidazo[2,1-b]thiazole-based aryl hydrazones: unravelling their synthesis and antiproliferative and apoptosis-inducing potential.

Authors:  Mohd Adil Shareef; Ganthala Parimala Devi; Sunitha Rani Routhu; C Ganesh Kumar; Ahmed Kamal; Bathini Nagendra Babu
Journal:  RSC Med Chem       Date:  2020-07-22

3.  Synthesis and anticancer activity of novel fused pyrimidine hybrids of myrrhanone C, a bicyclic triterpene of Commiphora mukul gum resin.

Authors:  Uppuluri Venkata Mallavadhani; Madasu Chandrashekhar; Vadithe Lakshma Nayak; Sistla Ramakrishna
Journal:  Mol Divers       Date:  2015-08-01       Impact factor: 2.943

4.  Design, synthesis and biological evaluation of imidazopyridine-propenone conjugates as potent tubulin inhibitors.

Authors:  Ibrahim Bin Sayeed; V Lakshma Nayak; Mohd Adil Shareef; Neeraj Kumar Chouhan; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-03-06       Impact factor: 3.597

5.  Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-c]pyrazole tethered carbohydrazide hybrids: exploring their in silico ADMET, ergosterol inhibition and ROS inducing potential.

Authors:  Mohd Adil Shareef; K Sirisha; Irfan Khan; Ibrahim Bin Sayeed; Surender Singh Jadav; Gopathi Ramu; C Ganesh Kumar; Ahmed Kamal; Bathini Nagendra Babu
Journal:  Medchemcomm       Date:  2019-04-26       Impact factor: 3.597

6.  New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors.

Authors:  Kishore Mullagiri; V Lakshma Nayak; Satish Sunkari; Geeta Sai Mani; Sravanthi Devi Guggilapu; Burri Nagaraju; Abdullah Alarifi; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-12-12       Impact factor: 3.597

7.  Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer.

Authors:  Merajuddin Khan; Mujeeb Khan; Abdulhadi H Al-Marri; Abdulrahman Al-Warthan; Hamad Z Alkhathlan; Mohammed Rafiq H Siddiqui; Vadithe Lakshma Nayak; Ahmed Kamal; Syed F Adil
Journal:  Int J Nanomedicine       Date:  2016-03-07

8.  Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies.

Authors:  Godshelp O Egharevba; Ahmed Kamal; Omotayo O Dosumu; Sunitha Routhu; Olatomide A Fadare; Stephen O Oguntoye; Stanislaus N Njinga; Abimbola P Oluyori
Journal:  Sci Rep       Date:  2022-02-03       Impact factor: 4.379
  8 in total

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