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Literature DB >> 17253959

A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells.

Wang-Kai Fang¹, Li-Yan Xu, Xiao-Feng Lu, Lian-Di Liao, Wei-Jia Cai, Zhong-Ying Shen, En-Min Li.

Abstract

Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway. To get a better understanding of NGAL function in oesophageal carcinoma, we analysed the expression of NGAL receptors in oesophageal carcinoma cells and identified a novel spliced variant designated NgalR-3. When expressed in a heterologous system, the protein produced from this novel spliced variant exhibits the biochemical characteristics of interaction and co-localization with NGAL protein in vivo. This new finding suggests that NgalR-3 may act as a potential NGAL receptor and play a role in NGAL-mediated iron transport in oesophageal carcinoma.

Entities: Chemical Disease Gene

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Year: 2007 PMID： 17253959 PMCID： PMC1874233 DOI： 10.1042/BJ20060836

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

26 in total

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12 in total

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Journal: Cancers (Basel) Date: 2014-04-04 Impact factor: 6.639