| Literature DB >> 17253858 |
Chung-Yi Chen1, Ching-Hsein Chen, Chung-Hang Wong, Yi-Wen Liu, Yu-Shan Lin, Yau-Der Wang, Yen-Ray Hsui.
Abstract
The aim of this study was to evaluate the cytotoxic effects of three new butanolides, subamolides A - C (1-3), and a new secobutanolide, secosubamolide (4), on the human colorectal cancer cell line SW480. Compounds 1-4 are new and were isolated from the stems of Cinnamomum subavenium, along with 17 known compounds. The structures of 1-4 were determined by spectroscopic analysis. Propidium iodide staining and flow cytometry were used to evaluate DNA damage of the treated SW480 cells, and it was found that 1-4 caused DNA damage in a dose-dependent manner after 24 h of treatment.Entities:
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Year: 2007 PMID： 17253858 DOI： 10.1021/np060425k
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050