| Literature DB >> 1725296 |
T Masaki1.
Abstract
Endothelin (ET-1) has many activities in various tissues and organs. Even in the vascular system, ET-1 elicits vasodilation as well as vasoconstriction. These diverse responses induced by ET-1 are ascribed to the balance between ET-1 and ET-3 effects that are mediated by (a) at least two types of calcium channel activated by ET, (b) three distinct prototypes of ET-receptor subtypes, (c) the diversity of the intracellular signal transduction system, especially cyclooxygenase products, and (d) modulation of hormonal and neuronal factors.Entities:
Mesh:
Substances:
Year: 1991 PMID: 1725296 DOI: 10.1097/00005344-199100177-00002
Source DB: PubMed Journal: J Cardiovasc Pharmacol ISSN: 0160-2446 Impact factor: 3.105