| Literature DB >> 17252255 |
A A Kurth1, A Heidenreich, I Diel.
Abstract
Since bone metastases occur as a result of hematogenous spreading of tumor cells, therapy with curative intent is no longer feasible and palliative options for treating and preventing skeletal events are essential. Today, bisphosphonates are established in the systemic treatment of bone metastases. This report provides an overview of molecular mechanisms of action and clinical data of bisphosphonates in patients with skeletal metastases of breast and prostate cancer as the most common solid tumors which spread to the bone.Entities:
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Year: 2007 PMID: 17252255 DOI: 10.1007/s00132-007-1051-1
Source DB: PubMed Journal: Orthopade ISSN: 0085-4530 Impact factor: 1.087