Literature DB >> 17252005

A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.

A Marinelli1, D Bossi, P G Pelicci, S Minucci.   

Abstract

Alterations of the retinoic acid receptor (RAR)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARalpha chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARbeta and RARgamma), through the generation and characterization of artificial PML-RAR'x' fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARalpha locus in leukemia patients must occur--rather than through functional differences among the various RAR isoforms-as the consequence of the nuclear architecture of the different RAR loci.

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Year:  2007        PMID： 17252005     DOI： 10.1038/sj.leu.2404572

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  8 in total

1.  Identification of a novel PML-RARG fusion in acute promyelocytic leukemia.

Authors:  J-S Ha; Y R Do; C-S Ki; C Lee; D-H Kim; W Lee; N-H Ryoo; D-S Jeon
Journal:  Leukemia       Date:  2017-05-30       Impact factor: 11.528

2.  A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion.

Authors:  Christopher A Miller; Christopher Tricarico; Zachary L Skidmore; Geoffrey L Uy; Yi-Shan Lee; Anjum Hassan; Michelle D O'Laughlin; Heather Schmidt; Ling Tian; Eric J Duncavage; Malachi Griffith; Obi L Griffith; John S Welch; Lukas D Wartman
Journal:  Blood Adv       Date:  2018-06-12

3.  Oncogenic activity of retinoic acid receptor γ is exhibited through activation of the Akt/NF-κB and Wnt/β-catenin pathways in cholangiocarcinoma.

Authors:  Gui-Li Huang; Qi Luo; Gang Rui; Wei Zhang; Qiu-Yan Zhang; Qing-Xi Chen; Dong-Yan Shen
Journal:  Mol Cell Biol       Date:  2013-06-24       Impact factor: 4.272

4.  Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.

Authors:  J J Qiu; B B Zeisig; S Li; W Liu; H Chu; Y Song; A Giordano; J Schwaller; H Gronemeyer; S Dong; C W E So
Journal:  Leukemia       Date:  2014-12-16       Impact factor: 11.528

Review 5.  RARG Gene Dysregulation in Acute Myeloid Leukemia.

Authors:  Maria Rosa Conserva; Immacolata Redavid; Luisa Anelli; Antonella Zagaria; Giorgina Specchia; Francesco Albano
Journal:  Front Mol Biosci       Date:  2019-10-24

6.  Case report: A rare case of acute myeloid leukemia with CPSF6-RARG fusion resembling acute promyelocytic leukemia.

Authors:  Junmei Zhao; Wentao Wang; Li Yan; Xi Chen; Wen Li; Wanying Li; Tingting Chen; Lunhua Chen
Journal:  Front Oncol       Date:  2022-09-15       Impact factor: 5.738

Review 7.  Classic and Variants APLs, as Viewed from a Therapy Response.

Authors:  Marie-Claude Geoffroy; Hugues de Thé
Journal:  Cancers (Basel)       Date:  2020-04-14       Impact factor: 6.639

8.  Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D.

Authors:  Ece Canan Sayitoglu; Anna-Maria Georgoudaki; Michael Chrobok; Didem Ozkazanc; Benjamin J Josey; Muhammad Arif; Kim Kusser; Michelle Hartman; Tamara M Chinn; Renee Potens; Cevriye Pamukcu; Robin Krueger; Cheng Zhang; Adil Mardinoglu; Evren Alici; Harry Thomas Temple; Tolga Sutlu; Adil Doganay Duru
Journal:  Front Immunol       Date:  2020-01-28       Impact factor: 7.561
  8 in total

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