| Literature DB >> 17251918 |
Seth J Corey1, Mark D Minden, Dwayne L Barber, Hagop Kantarjian, Jean C Y Wang, Aaron D Schimmer.
Abstract
The prevalence of patients with myelodysplastic syndromes (MDS) is increasing owing to an ageing population and increased awareness of these diseases. MDS represent many different conditions, not just a single disease, that are grouped together by several clinical characteristics. A striking feature of MDS is genetic instability, and a large proportion of cases result in acute myeloid leukaemia (AML). We Review three emerging principles of MDS biology: stem-cell dysfunction and the overlap with AML, genetic instability and the deregulation of apoptosis, in the context of inherited bone marrow-failure syndromes, and treatment-related MDS and AML.Entities:
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Year: 2007 PMID： 17251918 DOI： 10.1038/nrc2047
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716