OBJECTIVE: To test the hypothesis that electroencephalography has prognostic value in children after in-hospital cardiac arrest. DESIGN: Single-center, retrospective chart review. SETTING: Urban tertiary care children's hospital, January 2001 to July 2004. PATIENTS: Thirty-four consecutive children were identified from a registry of all patients resuscitated for cardiac arrest. Inclusion criteria were age >44 wks postmenstrual age to 18 yrs, survival after in-hospital cardiac arrest >24 hrs, and undergoing electroencephalography within 7 days after the cardiac arrest. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Prearrest, event, cardiopulmonary resuscitation, and postresuscitation variables were collected. Neurologic outcome was assessed by Pediatric Cerebral Performance Category (PCPC). Prearrest PCPC was estimated from chart review. Change in PCPC >1 or death between prearrest and time of hospital discharge was defined as poor neurologic outcome. Experts blinded to PCPC outcomes scored electroencephalographs from 1 (normal) to 5 (isoelectric). Sensitivity/specificity analysis and receiver operating characteristic curve were developed with each electroencephalography grade cutoff. Of 184 consecutive patients who had cardiac arrests in our registry, 107 survived >24 hrs, and 83 met study criteria. Thirty-four patients had electroencephalography within the first 7 days after the cardiac arrest. Among those, 16 (47%) patients had good neurologic outcome defined as no change in PCPC, and 18 (53%) died or had poor neurologic outcome. Univariate analysis showed that a higher electroencephalography score performed within 7 days was associated with poor neurologic outcome (p < .05). Positive predictive value of electroencephalography grade 4-5 for poor neurologic outcome was 90%, and negative predictive value of electroencephalography grade 1-2 for poor neurologic outcome was 91%. CONCLUSIONS: In a single-center consecutive case series, electroencephalography background patterns during the initial 7 days after in-hospital cardiac arrest were associated with neurologic outcome in children.
OBJECTIVE: To test the hypothesis that electroencephalography has prognostic value in children after in-hospital cardiac arrest. DESIGN: Single-center, retrospective chart review. SETTING: Urban tertiary care children's hospital, January 2001 to July 2004. PATIENTS: Thirty-four consecutive children were identified from a registry of all patients resuscitated for cardiac arrest. Inclusion criteria were age >44 wks postmenstrual age to 18 yrs, survival after in-hospital cardiac arrest >24 hrs, and undergoing electroencephalography within 7 days after the cardiac arrest. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Prearrest, event, cardiopulmonary resuscitation, and postresuscitation variables were collected. Neurologic outcome was assessed by Pediatric Cerebral Performance Category (PCPC). Prearrest PCPC was estimated from chart review. Change in PCPC >1 or death between prearrest and time of hospital discharge was defined as poor neurologic outcome. Experts blinded to PCPC outcomes scored electroencephalographs from 1 (normal) to 5 (isoelectric). Sensitivity/specificity analysis and receiver operating characteristic curve were developed with each electroencephalography grade cutoff. Of 184 consecutive patients who had cardiac arrests in our registry, 107 survived >24 hrs, and 83 met study criteria. Thirty-four patients had electroencephalography within the first 7 days after the cardiac arrest. Among those, 16 (47%) patients had good neurologic outcome defined as no change in PCPC, and 18 (53%) died or had poor neurologic outcome. Univariate analysis showed that a higher electroencephalography score performed within 7 days was associated with poor neurologic outcome (p < .05). Positive predictive value of electroencephalography grade 4-5 for poor neurologic outcome was 90%, and negative predictive value of electroencephalography grade 1-2 for poor neurologic outcome was 91%. CONCLUSIONS: In a single-center consecutive case series, electroencephalography background patterns during the initial 7 days after in-hospital cardiac arrest were associated with neurologic outcome in children.
Authors: Sudha Kilaru Kessler; Alexis A Topjian; Ana M Gutierrez-Colina; Rebecca N Ichord; Maureen Donnelly; Vinay M Nadkarni; Robert A Berg; Dennis J Dlugos; Robert R Clancy; Nicholas S Abend Journal: Neurocrit Care Date: 2011-02 Impact factor: 3.210
Authors: Rebecca Ichord; Faye S Silverstein; Beth S Slomine; Russell Telford; James Christensen; Richard Holubkov; J Michael Dean; Frank W Moler Journal: Neurology Date: 2018-06-08 Impact factor: 9.910
Authors: Allan R de Caen; Marc D Berg; Leon Chameides; Cheryl K Gooden; Robert W Hickey; Halden F Scott; Robert M Sutton; Janice A Tijssen; Alexis Topjian; Élise W van der Jagt; Stephen M Schexnayder; Ricardo A Samson Journal: Circulation Date: 2015-11-03 Impact factor: 29.690
Authors: Nicholas S Abend; Ram Mani; Tammy N Tschuda; Tae Chang; Alexis A Topjian; Maureen Donnelly; Denise LaFalce; Margaret C Krauss; Sarah E Schmitt; Joshua M Levine Journal: Am J Electroneurodiagnostic Technol Date: 2011-09
Authors: Ericka L Fink; Robert S B Clark; Patrick M Kochanek; Michael J Bell; R Scott Watson Journal: Pediatr Crit Care Med Date: 2010-01 Impact factor: 3.624