Literature DB >> 1725155

Triggered activity in the heart: cellular mechanisms of early after-depolarizations.

C T January1, V Chau, J C Makielski.   

Abstract

The arrhythmogenic effects of ischaemia and reperfusion result from the complex interplay of normal ion channels reacting to the ischaemic environment, channels made abnormal by ischaemic modification, the appearance of new currents normally not present, and possible ischaemic alteration of metabolic electrogenic processes. In this report the cellular mechanisms thought to underlie the different types of triggered activity will be discussed. The role of Ca2+ channels and Ca2+ 'window' current in the generation of early after-depolarizations (EADs) will be elucidated.

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Year:  1991        PMID： 1725155     DOI： 10.1093/eurheartj/12.suppl_f.4

Source DB:  PubMed          Journal:  Eur Heart J        ISSN： 0195-668X            Impact factor:   29.983


  19 in total

1.  Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome.

Authors:  Mitsunori Maruyama; Shien-Fong Lin; Yuanfang Xie; Su-Kiat Chua; Boyoung Joung; Seongwook Han; Tetsuji Shinohara; Mark J Shen; Zhilin Qu; James N Weiss; Peng-Sheng Chen
Journal:  Circ Arrhythm Electrophysiol       Date:  2010-11-15

2.  Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes.

Authors:  Zhen Song; Christopher Y Ko; Michael Nivala; James N Weiss; Zhilin Qu
Journal:  Biophys J       Date:  2015-04-21       Impact factor: 4.033

3.  An experimental model of the production of early after depolarizations by injury current from an ischemic region.

Authors:  R Kumar; R W Joyner
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657

Review 4.  Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve.

Authors:  Zhilin Qu; Lai-Hua Xie; Riccardo Olcese; Hrayr S Karagueuzian; Peng-Sheng Chen; Alan Garfinkel; James N Weiss
Journal:  Cardiovasc Res       Date:  2013-04-25       Impact factor: 10.787

5.  Imaging arrhythmogenic calcium signaling in intact hearts.

Authors:  Peng-Sheng Chen; Masahiro Ogawa; Mitsunori Maruyama; Su-Kiat Chua; Po-Cheng Chang; Michael Rubart-von der Lohe; Zhenhui Chen; Tomohiko Ai; Shien-Fong Lin
Journal:  Pediatr Cardiol       Date:  2012-02-17       Impact factor: 1.655

6.  Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.

Authors:  Igor Splawski; Katherine W Timothy; Niels Decher; Pradeep Kumar; Frank B Sachse; Alan H Beggs; Michael C Sanguinetti; Mark T Keating
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-29       Impact factor: 11.205

7.  Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.

Authors:  Andrew G Edwards; Eleonora Grandi; Johan E Hake; Sonia Patel; Pan Li; Shigeki Miyamoto; Jeffrey H Omens; Joan Heller Brown; Donald M Bers; Andrew D McCulloch
Journal:  Circ Arrhythm Electrophysiol       Date:  2014-09-18

8.  Arrhythmogenic consequences of myofibroblast-myocyte coupling.

Authors:  Thao P Nguyen; Yuanfang Xie; Alan Garfinkel; Zhilin Qu; James N Weiss
Journal:  Cardiovasc Res       Date:  2011-11-02       Impact factor: 10.787

9.  Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

Authors:  Lili Wang; Kyungsoo Kim; Shan Parikh; Adrian Gabriel Cadar; Kevin R Bersell; Huan He; Jose R Pinto; Dmytro O Kryshtal; Bjorn C Knollmann
Journal:  J Mol Cell Cardiol       Date:  2017-12-05       Impact factor: 5.000

10.  Differential effects of extracellular cesium on early afterdepolarizations in ventricular myocytes and arrhythmogenesis in isolated hearts of rats and guinea pigs.

Authors:  C Ian Spencer; John J Borg; Roland Z Kozlowski; James S K Sham
Journal:  Pflugers Arch       Date:  2004-05-12       Impact factor: 3.657
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