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Literature DB >> 17251382

Critical role of urea in the urine-concentrating mechanism.

Jeff M Sands.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17251382 DOI： 10.1681/ASN.2006121314

Source DB: PubMed Journal: J Am Soc Nephrol ISSN： 1046-6673 Impact factor: 10.121

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18 in total

1. Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity.

Authors: Hua Su; Conner B Carter; Otto Fröhlich; Richard D Cummings; Guangping Chen
Journal: Am J Physiol Renal Physiol Date: 2012-04-25

2. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.

Authors: Cristina Esteva-Font; Onur Cil; Puay-Wah Phuan; Tao Su; Sujin Lee; Marc O Anderson; A S Verkman
Journal: FASEB J Date: 2014-05-19 Impact factor: 5.191

3. A small molecule screen identifies selective inhibitors of urea transporter UT-A.

Authors: Cristina Esteva-Font; Puay-Wah Phuan; Marc O Anderson; A S Verkman
Journal: Chem Biol Date: 2013-09-19

4. Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

Authors: Renee R Handley; Suzanne J Reid; Rudiger Brauning; Paul Maclean; Emily R Mears; Imche Fourie; Stefano Patassini; Garth J S Cooper; Skye R Rudiger; Clive J McLaughlan; Paul J Verma; James F Gusella; Marcy E MacDonald; Henry J Waldvogel; C Simon Bawden; Richard L M Faull; Russell G Snell
Journal: Proc Natl Acad Sci U S A Date: 2017-12-11 Impact factor: 11.205

Critical role of urea in the urine-concentrating mechanism.

1. Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity.

2. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.

3. A small molecule screen identifies selective inhibitors of urea transporter UT-A.

4. Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases.

5. Regulation of renal urea transport by vasopressin.

Review 6. Small-molecule inhibitors of urea transporters.

7. Long-term dietary restriction up-regulates activity and expression of renal arginase II in aging mice.

Review 8. Urea transporter proteins as targets for small-molecule diuretics.

Review 9. Molecular mechanisms of urea transport in health and disease.

10. Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.