Literature DB >> 17250579

Dentine hypersensitivity: is there both stimulus and placebo responses in clinical trials?

M Addy1, N X West, A Barlow, S Smith.   

Abstract

AIM: To determine whether application of a periodontal dressing stopped pain arising from dentine hypersensitivity, objectively assessed with evaporative and thermal stimuli and recorded with Visual Analogue Scale scoring (VAS).
MATERIALS AND METHODS: 22 subjects completed the single-centre, subject-blind, stratified, randomized, split-mouth study, with a minimum of two sensitive teeth, in at least two different quadrants, displaying a response of >or=30 mm with VAS to evaporative stimulus. One tooth in two different quadrants was identified and randomized to test or control groups. A dressing was applied to all the sensitive teeth in the test quadrant, and either side of the chosen sensitive tooth on the control side. The test teeth were then stimulated for hypersensitivity using evaporative stimuli and then using thermal stimuli.
RESULTS: Analysis showed that dressing application produced significantly greater reduction in pain (P<0.0001) compared with no periodontal dressing. Single application of a dressing to sensitive dentine provided 95% pain relief associated with thermal stimulus and 85% pain relief associated with evaporative stimulus.
CONCLUSIONS: Application of the dressing to sensitive teeth, dramatically reduced the pain of dentine hypersensitivity following tooth stimulation. When assessing subjects' response to pain-evoking stimuli, perception of pain appears to be altered by sensory factors, prompting a heightened pain response.

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Mesh:

Year:  2007        PMID: 17250579     DOI: 10.1111/j.1601-5037.2007.00228.x

Source DB:  PubMed          Journal:  Int J Dent Hyg        ISSN: 1601-5029            Impact factor:   2.477


  7 in total

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Review 2.  How valid and applicable are current diagnostic criteria and assessment methods for dentin hypersensitivity? An overview.

Authors:  Christian R Gernhardt
Journal:  Clin Oral Investig       Date:  2012-12-06       Impact factor: 3.573

Review 3.  The role of fluoride in the preventive management of dentin hypersensitivity and root caries.

Authors:  Lars G Petersson
Journal:  Clin Oral Investig       Date:  2012-12-28       Impact factor: 3.573

4.  Using classification and regression tree modelling to investigate response shift patterns in dentine hypersensitivity.

Authors:  Carolina Machuca; Mario V Vettore; Marta Krasuska; Sarah R Baker; Peter G Robinson
Journal:  BMC Med Res Methodol       Date:  2017-08-14       Impact factor: 4.615

5.  Randomised clinical studies investigating immediate and short-term efficacy of an occluding toothpaste in providing dentine hypersensitivity relief.

Authors:  Jonathan Creeth; John Gallob; Farzana Sufi; Jimmy Qaqish; Paola Gomez-Pereira; Chandrashekhar Budhawant; Chhaju Goyal
Journal:  BMC Oral Health       Date:  2019-06-04       Impact factor: 2.757

6.  Remineralization and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: a comparative in vivo study.

Authors:  Marco Lelli; Angelo Putignano; Marco Marchetti; Ismaela Foltran; Francesco Mangani; Maurizio Procaccini; Norberto Roveri; Giovanna Orsini
Journal:  Front Physiol       Date:  2014-09-05       Impact factor: 4.566

7.  Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: A randomized controlled clinical trial.

Authors:  Mariangela Ivette Guanipa Ortiz; Cristiane de Melo Alencar; Brennda Lucy Freitas De Paula; Eliane Bemerguy Alves; Jesuína Lamartine Nogueira Araújo; Cecy Martins Silva
Journal:  PLoS One       Date:  2019-12-02       Impact factor: 3.752

  7 in total

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