Literature DB >> 1724678

The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol.

M L Steer1, P L Rutledge, R E Powers, M Saluja, A K Saluja.   

Abstract

The role of oxygen-derived free radicals was evaluated in two models of experimental acute pancreatitis by testing the effects of agents which either reduce oxygen-derived free radical generation or scavenge those free radicals. Those agents (catalase, superoxide dismutase, polyethylene glycol-superoxide dismutase, dimethylsulfoxide, and allopurinol) were evaluated using the choline-deficient ethionine-supplemented diet-induced model of acute hemorrhagic pancreatic necrosis and the supramaximal caerulein stimulation model of acute interstitial edematous pancreatitis. In both models, the only effect associated with administration of the test agents was a reduction in the degree of pancreatic edema. These results suggest that oxygen-derived free radicals may play an important role in the development of pancreatic edema during pancreatitis but that those free radicals do not play an important role in the development of acinar cell injury.

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Year:  1991        PMID： 1724678     DOI： 10.1007/bf01645149

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  20 in total

1.  Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulation.

Authors:  I Saito; S Hashimoto; A Saluja; M L Steer; J Meldolesi
Journal:  Am J Physiol       Date:  1987-10

2.  Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis.

Authors:  D B Gough; B Boyle; W P Joyce; C P Delaney; K F McGeeney; T F Gorey; J M Fitzpatrick
Journal:  Br J Surg       Date:  1990-11       Impact factor: 6.939

3.  Direct ESR measurement of free radicals in mouse pancreatic lesions.

Authors:  A Nonaka; T Manabe; N Asano; T Kyogoku; K Imanishi; K Tamura; T Tobe; Y Sugiura; K Makino
Journal:  Int J Pancreatol       Date:  1989-09

4.  Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis.

Authors:  O Watanabe; F M Baccino; M L Steer; J Meldolesi
Journal:  Am J Physiol       Date:  1984-04

5.  Superoxide dismutase and catalase: a possible role in established pancreatitis.

Authors:  K S Guice; D E Miller; K T Oldham; C M Townsend; J C Thompson
Journal:  Am J Surg       Date:  1986-01       Impact factor: 2.565

6.  Temporal efficacy of allopurinol during the induction of pancreatitis in the ex vivo perfused canine pancreas.

Authors:  M G Sarr; G B Bulkley; J L Cameron
Journal:  Surgery       Date:  1987-03       Impact factor: 3.982

7.  Evidence for a role of oxygen derived free radicals in the pathogenesis of caerulein induced acute pancreatitis in rats.

Authors:  J Wisner; D Green; L Ferrell; I Renner
Journal:  Gut       Date:  1988-11       Impact factor: 23.059

8.  Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue.

Authors:  M Lampel; H F Kern
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1977-03-11

9.  Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice.

Authors:  P L Rutledge; A K Saluja; R E Powers; M L Steer
Journal:  Gastroenterology       Date:  1987-07       Impact factor: 22.682

10.  The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis.

Authors:  H Sanfey; G B Bulkley; J L Cameron
Journal:  Ann Surg       Date:  1984-10       Impact factor: 12.969
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  9 in total

Review 1.  Free radicals and the pancreatic acinar cells: role in physiology and pathology.

Authors:  M Chvanov; O H Petersen; A Tepikin
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-12-29       Impact factor: 6.237

2.  Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats.

Authors:  W Qi; D X Tan; R J Reiter; S J Kim; L C Manchester; J Cabrera; R M Sainz; J C Mayo
Journal:  Dig Dis Sci       Date:  1999-11       Impact factor: 3.199

Review 3.  Calcium and reactive oxygen species in acute pancreatitis: friend or foe?

Authors:  David M Booth; Rajarshi Mukherjee; Robert Sutton; David N Criddle
Journal:  Antioxid Redox Signal       Date:  2011-08-23       Impact factor: 8.401

4.  Massive acinar cell apoptosis with secondary necrosis, origin of ducts in atrophic lobules and failure to regenerate in cyanohydroxybutene pancreatopathy in rats.

Authors:  L Kelly; L Reid; N I Walker
Journal:  Int J Exp Pathol       Date:  1999-08       Impact factor: 1.925

5.  Cu/Zn-SOD in human pancreatic tissue and pancreatic juice.

Authors:  D H Hausmann; T Porstmann; I Weber; S Hausmann; W Dummler; S Liebe; J Emmrich
Journal:  Int J Pancreatol       Date:  1997-12

6.  Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin.

Authors:  Helge Kleinhans; Oliver Mann; Paulus G Schurr; Jussuf T Kaifi; Bente Hansen; Jakob R Izbicki; Tim Strate
Journal:  World J Gastroenterol       Date:  2006-05-14       Impact factor: 5.742

7.  Cerulein-induced acute pancreatitis diminished vitamin E concentration in plasma and increased in the pancreas.

Authors:  J Antosiewicz; J Popinigis; H Ishiguro; T Hayakawa; T Wakabayashi
Journal:  Int J Pancreatol       Date:  1995-06

Review 8.  A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase.

Authors:  A Kooij
Journal:  Histochem J       Date:  1994-12

9.  Specific interaction of pancreatic elastase and leucocytes to produce oxygen radicals and its implication in pancreatitis.

Authors:  N Tsuji; N Watanabe; T Okamoto; Y Niitsu
Journal:  Gut       Date:  1994-11       Impact factor: 23.059
  9 in total

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