Literature DB >> 1724630

Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre.

B Allard1, V Jacquemond, F Lemtiri-Chlieh, B Pourrias, O Rougier.   

Abstract

1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. 4. The action of heptaminol was suppressed in sodium-free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. 5. These results could be explained by a stimulation of the Na/H antiport by heptaminol.

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Year:  1991        PMID： 1724630      PMCID： PMC1908234          DOI： 10.1111/j.1476-5381.1991.tb12493.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  24 in total

1.  [EFFECTS OF HEPTAMINOL HCL ON THE CONTRACTION, ACTION POTENTIAL AND INTRACELLULAR POTASSIUM LEVELS OF CARDIAC FIBERS].

Authors:  P MUELLER; H J SCHATZMANN; S WEIDMANN
Journal:  C R Seances Soc Biol Fil       Date:  1964

2.  [Heptaminol and nervous fatigue].

Authors:  P Chauchard; H Mazoue
Journal:  C R Seances Soc Biol Fil       Date:  1958

3.  [Study with the aid of intracellular microelectrodes of the action of a cardiotonic: 2-methyl-6-amino-2-heptanol on nodal tissue of dog heart].

Authors:  E CORABOEUF; J BOISTEL
Journal:  C R Seances Soc Biol Fil       Date:  1953-05

4.  [Actions of heptaminol HCl on the cardiovascular and curarizing effects of D-tubocurarine].

Authors:  A LOUBATIERES; P BOUYARD; A SASSINE; M M MARIANI
Journal:  C R Seances Soc Biol Fil       Date:  1961

Review 5.  The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.

Authors:  M Lazdunski; C Frelin; P Vigne
Journal:  J Mol Cell Cardiol       Date:  1985-11       Impact factor: 5.000

6.  The effect of amiloride on the resting potential and the electrical constants of frog skeletal muscle fibres.

Authors:  F Estrada; J A Sanchez
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

Review 7.  [Mechanisms of excitation-contraction coupling and calcium liberation in striated muscles of vertebrates].

Authors:  G Raymond
Journal:  Arch Int Physiol Biochim       Date:  1989-08

8.  Properties of the intracellular pH-regulating systems of frog skeletal muscle.

Authors:  R W Putnam; A Roos; T J Wilding
Journal:  J Physiol       Date:  1986-12       Impact factor: 5.182

9.  Decrease in internal H+ and positive inotropic effect of heptaminol hydrochloride: a 31P n.m.r. spectroscopy study in rat isolated heart.

Authors:  F Berthiau; D Garnier; J A Argibay; F Seguin; B Pourrias; J P Grivet; A Le Pape
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

10.  Nifedipine and BAY K inhibit contraction independently from their action on calcium channels.

Authors:  V Jacquemond; O Rougier
Journal:  Biochem Biophys Res Commun       Date:  1988-05-16       Impact factor: 3.575
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  2 in total

1.  Alteration of the L-type calcium current in guinea-pig single ventricular myocytes by heptaminol hydrochloride.

Authors:  N Peineau; K G Mongo; J Y Le Guennec; D Garnier; J A Argibay
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

2.  Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model.

Authors:  P Eyenga; D Roussel; B Rey; P Ndille; L Teulier; F Eyenga; C Romestaing; J Morel; V Gueguen-Chaignon; S-S Sheu
Journal:  Intensive Care Med Exp       Date:  2021-04-07
  2 in total

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