BACKGROUND: In the general population, diabetes mellitus (DM) is associated with age, minority race/ethnicity, and obesity. Among HIV-infected persons, antiretroviral therapy (ART) use and hepatitis C virus (HCV) infection have been associated with DM. This study examined DM prevalence and its predictors in ART-naive HIV-infected patients. METHODS: A cross-sectional analysis of ART-naive HIV-infected adults enrolled in 3 Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) clinical trials versus adults enrolled in the National Health and Nutritional Examination Survey (NHANES). RESULTS: The prevalence of DM in the CPCRA clinical trials versus the NHANES was 3.3% versus 4.8%. The mean body mass index (BMI) was lower in the CPCRA trials versus the NHANES (25 kg/m vs. 28 kg/m). HCV was associated with DM only in univariate analyses in the CPCRA trials. In univariate and multivariate analyses, race/ethnicity, age, and BMI were associated with DM in both cohorts. Among women, age and BMI were associated with DM in both cohorts; race/ethnicity was associated with DM only in the NHANES. HCV was predictive of DM in blacks in the CPCRA trials (P = 0.004 before adjustment for multiple comparisons) but not in the full cohort. CONCLUSIONS: Our findings did not suggest an increased prevalence of DM in ART-naive HIV-infected patients. Although there was a trend toward increased prevalence of DM in HIV-HCV-coinfected patients, dominant risk factors associated with DM among ART-naive HIV-infected adults mirrored those of the general population.
BACKGROUND: In the general population, diabetes mellitus (DM) is associated with age, minority race/ethnicity, and obesity. Among HIV-infectedpersons, antiretroviral therapy (ART) use and hepatitis C virus (HCV) infection have been associated with DM. This study examined DM prevalence and its predictors in ART-naive HIV-infectedpatients. METHODS: A cross-sectional analysis of ART-naive HIV-infected adults enrolled in 3 Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) clinical trials versus adults enrolled in the National Health and Nutritional Examination Survey (NHANES). RESULTS: The prevalence of DM in the CPCRA clinical trials versus the NHANES was 3.3% versus 4.8%. The mean body mass index (BMI) was lower in the CPCRA trials versus the NHANES (25 kg/m vs. 28 kg/m). HCV was associated with DM only in univariate analyses in the CPCRA trials. In univariate and multivariate analyses, race/ethnicity, age, and BMI were associated with DM in both cohorts. Among women, age and BMI were associated with DM in both cohorts; race/ethnicity was associated with DM only in the NHANES. HCV was predictive of DM in blacks in the CPCRA trials (P = 0.004 before adjustment for multiple comparisons) but not in the full cohort. CONCLUSIONS: Our findings did not suggest an increased prevalence of DM in ART-naive HIV-infectedpatients. Although there was a trend toward increased prevalence of DM in HIV-HCV-coinfectedpatients, dominant risk factors associated with DM among ART-naive HIV-infected adults mirrored those of the general population.
Authors: Allison Longenberger; Jeong Youn Lim; Todd T Brown; Alison Abraham; Frank J Palella; Rita B Effros; Trevor Orchard; Maria Mori Brooks; Lawrence A Kingsley Journal: Future Virol Date: 2011-04 Impact factor: 1.831
Authors: Allison Longenberger; Jeong Youn Lim; Trevor Orchard; Maria Mori Brooks; Jennifer Brach; Kristen Mertz; Lawrence A Kingsley Journal: Futur HIV Ther Date: 2008-11
Authors: Melissa A Frasco; Roksana Karim; David Van Den Berg; Richard M Watanabe; Kathryn Anastos; Mardge Cohen; Stephen J Gange; Deborah R Gustafson; Chenglong Liu; Phyllis C Tien; Wendy J Mack; Celeste L Pearce Journal: AIDS Date: 2014-07-31 Impact factor: 4.177
Authors: Adeel A Butt; Kathleen McGinnis; Maria C Rodriguez-Barradas; Stephen Crystal; Michael Simberkoff; Matthew Bidwell Goetz; David Leaf; Amy C Justice Journal: AIDS Date: 2009-06-19 Impact factor: 4.177