Literature DB >> 17244259

Delayed access to alcohol accelerates self-administration of alcohol on a progressive ratio schedule.

Chris Pickering1, Tiago Moreira, Sture Liljequist.   

Abstract

In a previous report, we found that a 5-min. delay in alcohol access increases ethanol intake in rats trained to self-administer 5% ethanol. To assess the effects of this delay on the motivation to self-administer ethanol, Wistar rats were trained on a progressive ratio schedule of reinforcement and presented with the 5-min. delay. There was no change in break point (6 presses/delivery), active (125 presses/30 min.) or inactive (10 presses/30 min.) lever presses after the 5-min. delay compared to baseline. However, response cessation occurred 10 min. earlier in this delay session compared to baseline indicating that consumption was accelerated by delayed access to alcohol.

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Year:  2007        PMID: 17244259     DOI: 10.1111/j.1742-7843.2006.00002.x

Source DB:  PubMed          Journal:  Basic Clin Pharmacol Toxicol        ISSN: 1742-7835            Impact factor:   4.080


  2 in total

1.  Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals.

Authors:  Chris Pickering; Johan Alsiö; Anna-Lena Hulting; Helgi B Schiöth
Journal:  Psychopharmacology (Berl)       Date:  2009-02-11       Impact factor: 4.530

2.  Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.

Authors:  Joyce Besheer; Sara Faccidomo; Julie J M Grondin; Clyde W Hodge
Journal:  Alcohol Clin Exp Res       Date:  2007-12-21       Impact factor: 3.455

  2 in total

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