UNLABELLED: To examine the relapse rate achievable in a real-life early psychosis treatment service. METHOD: A 2-year longitudinal cohort study of consecutive admissions to an early psychosis programme which served the entire population in a catchment area. The primary outcome measure was relapse. RESULTS: One hundred and forty-eight consecutive consenting admissions were recruited, 124 (83.8%) of whom were followed for 1 year and 116 (78.4%) for 2 years. Relapse was assessed by clinicians using structured criteria. The 2-year relapse rate among subjects with complete data collection was 34/95 (35.7%, 95% CI 26.2-46.3). A Kaplan-Meier life table censoring subjects lost to follow-up yielded a comparable estimate of the proportion not relapsing: 68% (95% CI 58-76%). CONCLUSION: These estimates compare favourably with a published range of 2-year relapse from 55% to 70% in the older literature and are comparable with the results in recent clinical trials.
UNLABELLED: To examine the relapse rate achievable in a real-life early psychosis treatment service. METHOD: A 2-year longitudinal cohort study of consecutive admissions to an early psychosis programme which served the entire population in a catchment area. The primary outcome measure was relapse. RESULTS: One hundred and forty-eight consecutive consenting admissions were recruited, 124 (83.8%) of whom were followed for 1 year and 116 (78.4%) for 2 years. Relapse was assessed by clinicians using structured criteria. The 2-year relapse rate among subjects with complete data collection was 34/95 (35.7%, 95% CI 26.2-46.3). A Kaplan-Meier life table censoring subjects lost to follow-up yielded a comparable estimate of the proportion not relapsing: 68% (95% CI 58-76%). CONCLUSION: These estimates compare favourably with a published range of 2-year relapse from 55% to 70% in the older literature and are comparable with the results in recent clinical trials.
Authors: John F M Gleeson; Sue M Cotton; Mario Alvarez-Jimenez; Darryl Wade; Donna Gee; Kingsley Crisp; Tracey Pearce; Daniela Spiliotacopoulos; Belinda Newman; Patrick D McGorry Journal: Schizophr Bull Date: 2011-11-29 Impact factor: 9.306
Authors: Ann Faerden; Elizabeth Ann Barrett; Ragnar Nesvåg; Svein Friis; Arnstein Finset; Stephen R Marder; Joseph Ventura; Ole A Andreassen; Ingrid Agartz; Ingrid Melle Journal: Psychiatry Res Date: 2013-03-13 Impact factor: 3.222
Authors: Shaunagh O'Sullivan; Lianne Schmaal; Simon D'Alfonso; Yara Jo Toenders; Lee Valentine; Carla McEnery; Sarah Bendall; Barnaby Nelson; John F Gleeson; Mario Alvarez-Jimenez Journal: JMIR Ment Health Date: 2022-04-07