Literature DB >> 17243720

Copper-catalyzed multicomponent cascade process for the synthesis of hexahydro-1H-isoindolones.

Lei Zhang1, Helena C Malinakova.   

Abstract

Copper-catalyzed coupling of imines, dienylstannanes, and acryloyl chlorides followed by a Diels-Alder reaction afforded hexahydro-1H-isoindolones. Diversification of the core via Pd-catalyzed cross-coupling defines a new modular approach to isoindolone combinatorial libraries.

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Year:  2007        PMID: 17243720     DOI: 10.1021/jo0621773

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.

Authors:  James D Sunderhaus; Chris Dockendorff; Stephen F Martin
Journal:  Tetrahedron       Date:  2009-09-15       Impact factor: 2.457

2.  Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.

Authors:  Thiruvellore Thatai Jayanth; Lei Zhang; Thomas S Johnson; Helena C Malinakova
Journal:  Org Lett       Date:  2009-02-19       Impact factor: 6.005

  2 in total

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