| Literature DB >> 1724348 |
E M O'Byrne1, R L Goldberg, J R Doughty, M Wong, V Blancuzzi, D Wilson, A Y Jeng.
Abstract
The effect of SP on recombinant human IL-1 alpha-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 micrograms SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 micrograms Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees.Entities:
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Year: 1991 PMID： 1724348 DOI： 10.1007/bf01993289
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299